有机化学 ›› 2019, Vol. 39 ›› Issue (7): 2018-2025.DOI: 10.6023/cjoc201901026 上一篇    下一篇

研究论文

碘诱导的醛糖与o-氨基苯甲酰胺的氧化缩合合成糖基喹唑啉酮

琚欢欢, 孙佳婧, 李小六, 陈华   

  1. 河北大学化学与环境科学学院 河北省化学生物学重点实验室 保定 071002
  • 收稿日期:2019-01-17 修回日期:2019-03-04 出版日期:2019-07-25 发布日期:2019-03-21
  • 通讯作者: 李小六, 陈华 E-mail:lixl@hbu.cn;hua-todd@163.com
  • 基金资助:

    国家自然科学基金(Nos.21772031,21372060)资助项目.

Synthesis of Aldo-quinazolinones by Iodine-Induced Oxidative Condensation of Aldoses and o-Aminobenzamides

Ju Huanhuan, Sun Jiajing, Li Xiaoliu, Chen Hua   

  1. Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002
  • Received:2019-01-17 Revised:2019-03-04 Online:2019-07-25 Published:2019-03-21
  • Contact: 10.6023/cjoc201901026 E-mail:lixl@hbu.cn;hua-todd@163.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21772031, 21372060).

以不保护的单/双糖和邻氨基苯甲酰胺为原料,通过碘诱导的氧化缩合一锅法反应,合成了系列糖基喹唑啉酮衍生物,产率30%~80%,为该类化合物的合成提供了一个有效方法.碘的用量对该反应有重要的影响.

关键词: 糖基喹唑啉酮, 氧化缩合, 碘诱导

A series of aldo-quinazolinones were synthesized by a one-pot iodine-induced oxidative condensation of the unprotected mono-/di-saccharides and o-aminobenzamides in the yields of 30%~80%, providing an effective protocol for the preparation of aldo-quinazolinones. The amount of iodine has an important effect on the reaction.

Key words: aldo-quinazolinone, oxidative condensation, iodine-induced