有机化学 ›› 2019, Vol. 39 ›› Issue (6): 1596-1612.DOI: 10.6023/cjoc201902001 上一篇    下一篇

所属专题: 碳氢活化合辑2018-2019 金属有机化学

综述与进展

基于I2催化的C-H键功能团化的研究进展

施兆江, 王连会, 崔秀灵   

  1. 华侨大学生物医学学院 分子药物教育部工程研究中心 福建省分子医学重点实验室 厦门市海洋与基因药物重点实验室 厦门 361021
  • 收稿日期:2019-04-10 修回日期:2019-04-24 发布日期:2019-04-11
  • 通讯作者: 王连会, 崔秀灵 E-mail:lianhui.wang@hqu.edu.cn;cuixl@hqu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21602064,21572072)、泉州市科技计划项目(No.2018C073R)、华侨大学研究生科研创新基金资助项目.

Recent Advances in the I2-Catalyzed C-H Bond Functionalizations

Shi Zhaojiang, Wang Lianhui, Cui Xiuling   

  1. Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021
  • Received:2019-04-10 Revised:2019-04-24 Published:2019-04-11
  • Contact: 10.6023/cjoc201902001 E-mail:lianhui.wang@hqu.edu.cn;cuixl@hqu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21602064, 21572072), the Science and Technology Project of Quanzhou City (No. 2018C073R), and the Postgraduates Innovative Fund in Scientific Research of Huaqiao University.

杂环化合物在医药、精细化工等领域具有广泛的应用价值.因此,开发高效的杂环构筑策略在有机合成中仍然具有强大的吸引力.近年来,基于I2催化的直接C-H功能团化反应已发展成为构筑杂环化合物的重要方法之一.在此,按化合物的成键类型(C-C、C-N/O/S),综述近年来该领域的重要研究进展,并做总结与展望.

关键词: 碘催化, 碳氢键活化, 杂环化合物

Heterocyclic compounds are widely applied in medicine, fine chemical engineering and the related industrial fields. Consequently, the development of efficient strategies for heterocycle constructions continues to be of great appeal in organic synthesis. In recent years, the I2-catalyzed direct C-H bond functionalizations have emerged as one of the most efficient synthetic protocols to construct diverse heterocycles. In this review, the recent advances in I2-catalyzed C-H bond functionalizations by the types of C-C and C-N/O/S bond formations are summarized, and an outlook of this research filed is given.

Key words: I2-catalysis, C-H bond activation, heterocycles