有机化学 ›› 2019, Vol. 39 ›› Issue (10): 2685-2704.DOI: 10.6023/cjoc201903058    下一篇

综述与进展

二聚环色胺生物碱的全合成研究进展

沈先福ab, 彭天凤a, 周永云b, 奚永开b, 赵静峰b, 羊晓东b, 张洪彬b*()   

  1. a 曲靖师范学院 云贵高原化学功能材料与污染治理研究中心 生物资源与食品工程学院 云南曲靖 655011
    b 云南大学 云南省天然产物转化与利用及教育部自然资源药物化学重点实验室 昆明 650091
  • 收稿日期:2019-03-26 修回日期:2019-04-18 发布日期:2019-05-10
  • 通讯作者: 张洪彬 E-mail:zhanghb@ynu.edu.cn
  • 基金资助:
    长江学者和创新团队发展计划(IRT17R94);国家自然科学基金(2152197);国家自然科学基金(21861032);云南省自然科学基金(2018FD078);云南省自然科学基金(2017FH001-020);曲靖师范学院资助项目(2018QN002)

Progress in Total Syntheses of Dimeric Cyclotryptamine Alkaloids

Shen Xianfuab, Peng Tianfenga, Zhou Yongyunb, Xi Yongkaib, Zhao Jingfengb, Yang Xiaodongb, Zhang Hongbinb*()   

  1. a Center for Yunnan-Guizhou Plateau Chemical Functional Materials and Pollution Control, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing 655011, Yunnan
    b Key Laboratory of Natural Products Transformation and Utilization in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, Kunming 650091
  • Received:2019-03-26 Revised:2019-04-18 Published:2019-05-10
  • Contact: Zhang Hongbin E-mail:zhanghb@ynu.edu.cn
  • Supported by:
    Project supported by the Program for Changjiang Scholars and Innovative Research Team in University(IRT17R94);The National Natural Science Foundation of China(2152197);The National Natural Science Foundation of China(21861032);The Natural Science Foundation of Yunnan Province(2018FD078);The Natural Science Foundation of Yunnan Province(2017FH001-020);The Qujing Normal University(2018QN002)

二聚环色胺生物碱具有相邻的立体位阻较大的全碳季碳中心和良好的生物活性, 作为合成目标一直吸引着合成化学家的广泛关注. 立体选择地构建这类生物碱中相邻的全碳季碳中心是该类型分子化学合成的挑战. 综述总结了二聚环色胺生物碱十二年来的全合成研究进展.

关键词: 二聚环色胺, 生物碱, 相邻季碳, 氧化吲哚, 全合成

As interesting synthetic targets, dimeric cyclotryptamine alkaloids bearing sterically hindered vicinal all-carbon quaternary stereocenters have attracted significant attention from the synthetic community. Stereocontrolled synthesis of the congested all-carbon quaternary stereocenters in these alkaloids presents a formidable challenge. This review summarizes the synthetic efforts towards dimeric cyclotryptamine alkaloids in the last twelve years.

Key words: dimeric cyclotryptamine, alkaloids, vicinal quaternary carbons, oxindole, total synthesis