有机化学 ›› 2019, Vol. 39 ›› Issue (11): 2989-3012.DOI: 10.6023/cjoc201904037    下一篇

综述与进展

铜催化N-O键断裂策略研究进展

雷禄ab, 李承璟a, 莫冬亮a*()   

  1. a广西师范大学化学与药学学院 省部共建药用资源化学与药物分子工程国家重点实验室 桂林 541004
    b 百色学院化学与环境工程学院 广西百色 533000
  • 收稿日期:2019-04-14 出版日期:2019-11-25 发布日期:2019-07-03
  • 通讯作者: 莫冬亮 E-mail:moeastlight@mailbox.gxnu.edu.cn
  • 基金资助:
    广西高校百人计划、广西高校千名中青年骨干教师培育计划、广西自然科学基金(2016GXNSFFA380005)

Recent Advances in Copper-Catalyzed N-O Cleavage Strategy

Lei Luab, Li Chengjinga, Mo Donglianga*()   

  1. a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004
    b College of Chemistry & Environment Engineering, Baise University, Baise, Guangxi 533000
  • Received:2019-04-14 Online:2019-11-25 Published:2019-07-03
  • Contact: Mo Dongliang E-mail:moeastlight@mailbox.gxnu.edu.cn
  • Supported by:
    the "Overseas 100 Talents Program" of Guangxi Higher Education, the "One Thousand Young and Middle-Aged College and University Backbone Teachers Cultivation Program" of Guangxi Zhuang Autonomous Region, and the Natural Science Foundation of Guangxi Zhuang Autonomous Region(2016GXNSFFA380005)

N-O键断裂反应是向化合物中引入含氮、氧官能团的有效策略之一.铜催化剂来源丰富,价格便宜,铜催化剂在有机合成中占有不可替代的地位.铜催化的N-O断裂,由于具有反应条件温和、官能团兼容性好、原子经济性高等优点,在有机合成中被广泛应用于构建C-N和C-O键.N-O键的断裂策略在复杂天然产物及药物分子的合成中都有成功的应用.综述了近些年来铜金属催化N-O断裂的新策略及N-O断裂策略在天然产物和药物分子合成中的应用.

关键词: 铜催化, 杂环化合物, N-O断裂, 串联反应, 重排反应

N-O bond cleavage is one of the most efficient and powerful strategies to introduce N-or O-functional groups into molecules in organic synthesis. Copper catalyst, as the abundant in earth and inexpensive advantages has been widely used to construct C-N and C-O bond. Furthermore, N-O bond cleavage has been successfully applied in the total synthesis of natural products and pharmaceuticals. The new development of copper-catalyzed N-O bond cleavage and its application in the total synthesis of natural products and pharmaceuticals in recent years have been summarized.

Key words: copper-catalysis, heterocyclic compounds, N-O cleavage, cascade reaction, rearrangement reaction