有机化学 ›› 2020, Vol. 40 ›› Issue (10): 3044-3064.DOI: 10.6023/cjoc202005095 上一篇    下一篇

综述与进展

过渡金属催化不对称氧化反应方法研究进展

姚彪, 巫佳浩, 汪钰, 江焕峰   

  1. 华南理工大学化学与化工学院 广东省功能分子工程重点实验室 广州 510641
  • 收稿日期:2020-05-31 修回日期:2020-07-06 发布日期:2020-08-11
  • 通讯作者: 江焕峰 E-mail:jianghf@scut.edu.cn
  • 基金资助:
    国家重点研发计划(No.2016YFA06002900)和广东省重点领域研发(No.2020B010188001)资助项目.

Methods of Transition Metal-Catalyzed Asymmetric Oxidation

Yao Biao, Wu Jiahao, Wang Yu, Jiang Huanfeng   

  1. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641
  • Received:2020-05-31 Revised:2020-07-06 Published:2020-08-11
  • Supported by:
    Project supported by the National Key Research and Development Program of China (No. 2016YFA06002900) and the Key Research and Development Program of Guangdong Province (No. 2020B010188001).

过渡金属催化的不对称氧化反应,作为不对称合成的重要研究内容之一,为手性天然产物和药物的合成提供了实用便捷途径,因此其方法研究备受人们关注.重点介绍了近年来过渡金属催化的烯烃不对称氧化官能团化反应、C—H键不对称氧化反应、不对称BV氧化反应和硫醚不对称氧化反应等研究进展,并展望其未来发展趋势.

关键词: 过渡金属催化, 不对称氧化, 对映选择性, 烯烃, 碳-氢活化

Transition metal-catalyzed asymmetric oxidation, as one of important research targets of chiral synthesis, provides a direct, practical route for the synthesis of various chiral bioactive products and drugs, and has received much attention. The recent progress of the methods of transition metal-catalyzed asymmetric oxidation, especially, asymmetric oxidative functionalization of olefins, C-H bond asymmetric oxidation reaction, asymmetric BV oxidation and sulfide asymmetric oxidation is elaborated. Outlook of those issuesis is also discussed.

Key words: transition metal catalysis, asymmetric oxidation, enantioselectivity, olefin, C-H activation