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研究简报

钯催化的1,4-环己烯的立体选择性1,3-双芳基化反应

庞海亮, 吴冬, 阴国印   

  1. 武汉大学高等研究院 武汉 430072
  • 收稿日期:2020-06-12 修回日期:2020-08-28 出版日期:2030-01-01 发布日期:2020-09-16
  • 通讯作者: 阴国印 E-mail:yinguoyin@whu.edu.cn.
  • 基金资助:
    国家自然科学基金(Nos.21702151,21871211)和中央大学基础研究基金(No.2042019kf0208)资助项目.

Palladium-Catalyzed Stereoselective 1,3-Diarylation of 1,4-Cyclohexadiene

Pang Hailiang, Wu Dong, Yin Guoyin   

  1. Institute for Advanced Studies, Wuhan University, Wuhan 430072
  • Received:2020-06-12 Revised:2020-08-28 Online:2030-01-01 Published:2020-09-16
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21702151, 21871211) and the Fundamental Research Funds for Central Universities (No. 2042019kf0208).

基于金属迁移的策略,发展了钯催化的1,4-环己二烯的1,3-双芳基化反应,此反应具有优秀的区域选择性和单一的非对映选择性。反应可以得到单一的非对映选择性的双芳基化的产物,表明在钯迁移的过程中烯烃并没有从钯上解离下来。这一研究为cis-1,3-双芳基取代的环己烷类化合物的合成提供了简单的方法。

关键词: 钯催化, 金属迁移, 烯烃, 立体选择性

A palladium-catalyzed migratory diarylation of unconjugated cyclohexadiene is disclosed. This reaction exihibits high 1,3-regioselectivity and exclusive cis-diastereoselectivity. The excellent selectivity suggests the olefin does not dissocate from the palladium during chain-walking. The method allows for the synthesis of 1,3-diaryl-substituted cyclohexanes from the readily accessible materials.

Key words: palladium catalysis, metal migration, alkene, stereoselectivity