有机化学    下一篇

综述与进展

过渡金属催化合成吡咯-2-甲酸酯化合物的研究进展

李辞a, 李明瑞b, 谢宇星a, 于杨b, 黄菲a,b   

  1. a 南京师范大学 食品与制药工程学院 南京 210023;
    b 南京工业大学 药学院 南京 211816
  • 收稿日期:2020-06-23 修回日期:2020-08-10 出版日期:2030-01-01 发布日期:2020-08-31
  • 通讯作者: 黄菲 E-mail:huangfei0208@yeah.net
  • 基金资助:
    国家自然科学基金青年科学基金项目(21901124)和江苏省高等学校自然科学研究面上项目(19KJB150032)资助.

Progress in the Synthesis of Pyrrole-2-carboxylate Compounds Catalyzed by Transition Metals

Li Cia, Li Mingruib, Xie Yuxinga, Yu Yangb, Huang Feia,b   

  1. a School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023;
    b School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816
  • Received:2020-06-23 Revised:2020-08-10 Online:2030-01-01 Published:2020-08-31
  • Supported by:
    Project supported by National Natural Science Foundation of China (21901124) and Natural Science Foundation of the Jiangsu Higher Education Institutions of China (19KJB150032).

吡咯-2-甲酸酯广泛存在于生物活性分子中,在医药领域具有十分重要的的应用,因此吡咯-2-甲酸酯类化合物的合成研究受到了广泛关注。过渡金属催化的环加成反应在合成吡咯骨架方面应用广泛,具有区域选择性专一的优点。且过渡金属配体导向的C-N键构筑方法具有较高的原子步骤经济性、高效性、反应条件温和以及高选择性等优点。本文按照过渡金属催化剂分类,对吡咯-2-甲酸酯的[3+2]、[4+1]与[2+2+1]等成环反应的合成方法进行综述,介绍了过渡金属催化吡咯-2-甲酸酯化合物的机理及其应用,并对吡咯-2-甲酸酯的合成进行了展望。

关键词: 吡咯-2-甲酸酯, 过渡金属催化, C-N键构筑

Pyrrole-2-carboxylates widely exist in biologically active molecules and have many important applications in the field of medicine. Therefore, the synthesis of pyrrole-2-carboxylates has received extensive attention. The cycloaddition reactions that transition metal-catalyzed are widely used in the synthesis of pyrrole skeletons and have the advantages of regioselectivity. The formation methods of C-N bonds directed by transition metal ligand have some advantages, such as milder reaction conditions, higher atomic step economy, efficiency and selectivity. The reactions of[3+2],[4+1] and[2+2+1] cycloaddition, reaction mechanism and application of pyrrole-2-carboxylate compounds are introduced under various transition-metal conditions. The prospects of synthesis of pyrrole-2-carboxylates are also discussed.

Key words: pyrrole-2-carboxylate, transition metal catalysis, C-N bond formation