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综述与进展

线虫孵化信息素Glycinoeclepin A的生物活性及合成研究进展

马丁a,b, 敖军礼a,b, 胡乃峰a, 梁广鑫b   

  1. a 南开大学 元素有机化学国家重点实验室 天津 300071;
    b 上海科技大学 物质科学与技术学院 上海 201210
  • 收稿日期:2020-06-29 修回日期:2020-08-04 出版日期:2030-01-01 发布日期:2020-09-09
  • 通讯作者: 梁广鑫 E-mail:lianggx@shanghaitech.edu.cn
  • 基金资助:
    国家重点研发计划(No.2017YFD0201404)资助项目.

Progress in Biological Activity and Synthesis of Nematode Hatching Pheromone Glycinoeclepin A

Ding Maa,b, Junli Aoa,b, Naifeng Hua, Guangxin Liangb   

  1. a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071;
    b School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210
  • Received:2020-06-29 Revised:2020-08-04 Online:2030-01-01 Published:2020-09-09
  • Supported by:
    Project supported by the National Key Research and Development Program of China (No. 2017YFD0201404).

大豆胞囊线虫病作为影响大豆产量的主要病害之一,不仅给全世界大豆主产地带来了严重的经济损失,而且非常难以防治.Glycinoeclepin A是一个从四季豆根系的干粉中提取纯化得到的化学信息素,能够特异性地促进大豆胞囊线虫孵化,其生物活性可达10-12 g/mL(25℃,水溶液),具有成为新型杀线虫绿色生物农药的巨大潜质.本文概述了大豆胞囊线虫的繁殖与传统防治方法,glycinoeclepin A的分离与生物活性,以及自其发现以来,全世界有机合成化学家对该天然产物的全合成和构效关系研究进展.

关键词: 大豆胞囊线虫, 化学感受作用, glycinoeclepin A, 全合成, 构效关系

Soybean cyst nematode disease, one of the main diseases impacting the production of soybean, is very difficult to control and brings serious economic losses all over the world. Glycinoeclepin A is a chemical pheromone extracted and purified from the dry powder of string bean roots. It can specifically stimulate the hatching of soybean cyst nematodes, with a biological activity of 10-12 g/mL (25℃, aqueous solution). Potentially, glycinoeclepin A can serve as a new type of green biological pesticide for controlling soybean cyst nematode disease. This article provides a comprehensive overview on soybean cyst nematode disease, current methods in fighting it, the bioactivity studies on glycinoeclepin A, as well as the progress in the total synthesis and structure-activity relationship of this natural product since its discovery.

Key words: soybean cyst nematode, chemoreception, glycinoeclepin A, total synthesis, structure-activity relationship