有机化学 ›› 2021, Vol. 41 ›› Issue (1): 407-411.DOI: 10.6023/cjoc202007011 上一篇    下一篇

所属专题: 有机硅化学合辑

研究简报

炔丙醇与烯醇硅醚的直接亲核取代反应

李鑫玲a, 刘会丽a, 张顺吉a,*()   

  1. a 淮北师范大学化学与材料科学学院 安徽淮北 235000
  • 收稿日期:2020-07-04 修回日期:2020-08-06 发布日期:2020-08-27
  • 通讯作者: 张顺吉
  • 作者简介:
    * Corresponding authors. E-mail:

Direct Nucleophilic Substitution of Propargyl Alcohols with Enoxysilanes

Xinling Lia, Huili Liua, Shunji Zhanga,*()   

  1. a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000
  • Received:2020-07-04 Revised:2020-08-06 Published:2020-08-27
  • Contact: Shunji Zhang

报道了一种在对甲苯磺酸催化下炔丙醇和烯醇硅醚的直接亲核取代反应, 并有效合成 γ-炔基酮类化合物的新方法. 该反应在敞口环境下使用未经干燥处理的溶剂即可获得良好的产率.

关键词: 炔丙醇, 烯醇硅醚, 亲核取代, 催化, 对甲苯磺酸

A novel and efficient synthesis of γ-alkynyl ketones by the direct nucleophilic substitution of propargyl alcohols with enoxysilanes in the presence of a catalytic amount of p-toluenesulfonic acid monohydrate, has been developed. The reactions can be performed in an undried solvent under an air atmosphere to obtain the desired products in good yields.

Key words: Keywords propargyl alcohol, enoxysilane, nucleophilic substitution, catalyzed, p-toluenesulfonic acid