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研究简报

炔丙醇与烯醇硅醚的直接亲核取代反应

李鑫玲, 刘会丽, 张顺吉   

  1. 淮北师范大学化学与材料科学学院 淮北 235000
  • 收稿日期:2020-07-04 修回日期:2020-08-06 出版日期:2030-01-01 发布日期:2020-08-27
  • 通讯作者: 张顺吉 E-mail:sjzhang@chnu.edu.cn

Direct Nucleophilic Substitution of Propargyl Alcohols with Enoxysilanes

Li Xinling, Liu Huili, Zhang Shunji   

  1. Department of Chemistry, Huaibei Normal University, Huaibei, 235000
  • Received:2020-07-04 Revised:2020-08-06 Online:2030-01-01 Published:2020-08-27

报道了一种在对甲苯磺酸催化下,炔丙醇和烯醇硅醚的直接亲核取代反应,有效合成γ–炔基酮类化合物的新方法。该反应在敞口环境下使用未经干燥处理的溶剂即可获得良好的产率。

关键词: 炔丙醇, 烯醇硅醚, 亲核取代, 催化, 对甲苯磺酸

A novel and efficient synthesis of γ-alkynyl ketones by the direct nucleophilic substitution of propargyl alcohols with enoxysilanes in the presence of a catalytic amount of p-toluenesulfonic acid monohydrate, has been developed. The reactions can be performed in an undried solvent under an air atmosphere to obtain the desired products in good yields.

Key words: propargyl alcohol, enoxysilane, nucleophilic substitution, catalyzed, p-toluenesulfonic