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综述与进展

多组分参与的氟烷基化反应研究进展

潘军, 吴晶晶, 吴范宏   

  1. 上海应用技术大学化学与环境工程学院 上海绿色氟代制药工程技术研究中心 上海 201418
  • 收稿日期:2020-07-08 修回日期:2020-08-09 出版日期:2030-01-01 发布日期:2020-09-16
  • 通讯作者: 吴晶晶, 吴范宏 E-mail:wfh@sit.edu.cn;wjj@sit.edu.cn
  • 基金资助:
    国家自然科学基金(Nos.21672151,21602136)资助项目.

Progress in fluoroalkylation of multicomponent

Pan Jun, Wu Jingjing, Wu Fanhong   

  1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology, Shanghai, 201418
  • Received:2020-07-08 Revised:2020-08-09 Online:2030-01-01 Published:2020-09-16
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21672151, 21602136).

多组分参与的氟烷基化反应是当前有机氟化学研究的一个热点。在过去的几年里,由于新试剂新方法的发展,多组分参与的氟烷基化反应取得了长足的发展,不仅可以经济有效的一步将氟烷基基团与其他官能团同步引入,而且可以将起始原料转化为多种含有生物活性或药物活性的化合物。在这篇综述里面,我们首次全面地总结了多组分参与的氟烷基化反应在过去近十年时间里的发展进程。主要分为:三组分二氟烷基化反应、三组分三氟甲基化反应、三组分全氟烷基化反应、三组分单氟烷基化反应、三组分氟化反应以及四组分氟烷基化反应。同时对该类反应进行了总结和展望。

关键词: 多组分, 双官能团化, 二氟烷基化, 三氟甲基化, 全氟烷基化, 单氟烷基化, 氟化反应

Multi-component fluoroalkylation is a hot topic in organic fluorine chemistry. In the past few years, due to the development of new reagents and new methods, multi-component fluoroalkylation reactions have made great progress, which can not only economical and effective to introduce fluoroalkyl groups synchronously with other functional groups in one step, but also convert starting materials into a variety of compounds with biological or pharmaceutical activities. In this review, we present for the first time a comprehensive overview of the development of multi-component fluoroalkylation over the past decade. It can be divided into seven parts:three-component difluoroalkylation reaction, three-component trifluoroalkylation reaction, three-component perfluoroalkylation reaction, three-component monofluoroalkylation reaction, three-component fluorination and four-component fluoroalkylation. At the same time, this kind of reaction is summarized and prospected.

Key words: multicomponent, bifunctionalization, difluoroalkylation, trifluoromethylation, perfluoroalkylation, monofluoroalkylation, fluorination