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研究简报

水相中可见光下苯甲醇氧化合成喹唑啉酮衍生物的研究

张帆a,b, 侯慧青b, 许秀枝b, 陈志涛b, 柯方b   

  1. a 福建医科大学附属第一医院肿瘤内科 福州 350005;
    b 福建医科大学药学院, 福建省天然药物药理学重点实验室 福州 350004
  • 收稿日期:2020-07-09 修回日期:2020-08-20 出版日期:2030-01-01 发布日期:2020-09-16
  • 通讯作者: 柯方 E-mail:kefang612@163.com
  • 基金资助:
    福建省自然科学基金(Nos.2016Y9052,2016Y9053,2017J01820,FJNMP-201902,2017-1-64)资助项目.

Visible-Light-Induced Preparation of Quinazolinones by Oxidation of Benzyl Alcohols in Water

Zhang Fana,b, Hou Huiqingb, Xu Xiuzhib, Chen Zhitaob, Ke Fangb   

  1. a The First Affiliated Hospital of Fujian Medical University, Department of Oncology Fuzhou 350005;
    b Department of Pharmacy, Fujian Medical University, Fujian Provincial Key Laboratory of Natural Medicine Pharmacolog Fuzhou 350004
  • Received:2020-07-09 Revised:2020-08-20 Online:2030-01-01 Published:2020-09-16
  • Supported by:
    Project supported by the Natural Science Foundation of Fujian Province (Nos. 2016Y9052, 2016Y9053, 2017J01820, FJNMP-201902, 2017-1-64)

通过在水相中可见光下2-氨基苯甲酰胺与苄醇氧化制备喹唑啉酮的环化反应,应用廉价易得、操作简单的单质碘作为光催化剂,在室温下反应获得较好收率的产物.生成的目标产物最高产率可达到92%,为喹唑啉酮类化合物的合成提供了一种绿色经济的方法.运用此策略合成的N-(2-氟-5-甲基苯基)-6-(2,2,2-三氟乙氧基)蝶啶-4-胺对肿瘤细胞具有明显的抑制活性.

关键词: 可见光, 单质碘, 喹唑啉酮, 氧化剂, 催化剂

A novel visible-light-introduced reaction for the construction of quinazolinone derivatives via radical cyclization of 2-aminobenzamides with benzyl alochols under water phase has been developed. The reaction has been achieved in high yield under mild conditions by using I2 as photocatalyst, which is cheap, available and easy to handle. A variety of quinazolinones were obtained in yields up to 92%. It might provide a promising protocol for the synthesis of quinazolinone derivatives. Its application was performed by the synthesis of N-(2-fluoro-5-methylphenyl)-6-(2,2,2-trifluoroethoxy)pteridin-4-amine, which displayed significant inhibitory activity.

Key words: visible light, Iodine, quinazolinone, oxidant, catalyst