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综述与进展

2-碘酰基苯甲酸在有机合成中的研究与应用

张书瑜, 吴昊天, 汤峨   

  1. 云南大学自然资源药物化学教育部重点实验室 云南大学化学科学与工程学院 昆明 650091
  • 收稿日期:2020-07-09 修回日期:2020-08-11 出版日期:2030-01-01 发布日期:2020-09-16
  • 通讯作者: 汤峨 E-mail:tange@ynu.edu.cn
  • 基金资助:
    长江学者和创新团队发展计划(IRT13095),国家自然科学基金(21762046),云南科技厅—云南大学“双一流”建设联合基金(2018FY001),云南省高校科技创新团队支持计划资助项目.

Research and Application of 2-Iodoxybenzoic Acid in Organic Synthesis

Zhang Shuyu, Wu Haotian, Tang E   

  1. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091
  • Received:2020-07-09 Revised:2020-08-11 Online:2030-01-01 Published:2020-09-16
  • Supported by:
    Project supported by the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13095), the Natural Science Foundation of China (No. 21762046), Yunnan University Youth Talent, the Program for Yunnan Provincial Department of Science and Technology-Yunnan University Joint Fund (No. 2018FY001), the Program for Innovative Research Team of Yunnan Province.

高价有机碘化合物的反应性质与过渡金属相似,其参与的反应具有反应条件较温和,选择性好,产率高,环境友好等优点,因而近年来关于高价有机碘试剂的研究受到广泛关注,在有机合成领域中获得了较多应用。本文综述了近年来高价有机碘试剂2-碘酰基苯基酸在有机合成中的研究及应用,包括IBX在氧化羟基、含氮化合物、含硫化合物,在制备αβ-不饱和羰基化合物和αβ-不饱和酯,以及在不对称合成等方面的应用。最后介绍了近期对IBX的改进。

关键词: 2-碘酰基苯甲酸, 氧化, 有机合成, 高价有机碘

High-valent organoiodine reagents have many reaction characteristics similar to transition metals, and high-valent organoiodine-mediated reactions feature mild reaction conditions, good product selectivity, high yield and environmental friendliness. Therefore, they have been widely studied and applied in organic synthesis. This paper reviews the recent research progress of 2-iodoxybenzoic acid in organic synthesis, including the oxidation of hydroxyl group, nitrogen-containing compounds, and sulfur-containing compounds, the preparation of α, β-unsaturated carbonyl compounds and esters, and the application in asymmetric synthesis etal. The recent improvement of IBX is also introduced.

Key words: 2-iodoxybenzoic acid (IBX), oxidation, organic synthesis, high-valent organoiodine