有机化学 ›› 2006, Vol. 26 ›› Issue (12): 1623-1630. 上一篇    下一篇

综述与进展

2-碘酰基苯甲酸(2-Iodoxybenzoic acid, IBX)在有机合成中的应用

覃开云,苏桂发*,饶万平,谭光明   

  1. (广西师范大学化学化工学院 桂林 541004)
  • 收稿日期:2005-04-19 修回日期:2006-03-10 出版日期:2006-11-21 发布日期:2006-11-21
  • 通讯作者: 苏桂发

Application of 2-Iodoxybenzoic Acid (IBX) in Organic Synthesis

QIN Kai-Yun,SU Gui-Fa*,RAO Wan-Ping,TAN Guang-Ming   

  1. (College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004)
  • Received:2005-04-19 Revised:2006-03-10 Online:2006-11-21 Published:2006-11-21
  • Contact: SU Gui-Fa

综述了近年来2-碘酰基苯甲酸(2-iodoxybenzoic acid, IBX)在有机合成中的应用, 重点评述了IBX对醇类、含氮有机物、含硫有机物、连接在芳环上的碳原子的氧化反应, 探讨了IBX在α,β-不饱和羰基化合物和内酯合成中的应用, 这些反应具有反应条件温和、产率高、选择性好等优点. 简单介绍了IBX的一些新衍生物的合成及应用.

关键词: 2-碘酰基苯甲酸(IBX), 有机合成, 应用

This paper reviews the applications of 2-iodoxybenzoic acid (IBX) in organic synthesis, focusing on the oxidations of IBX with alcohols, nitrogen-containing, sulfur-containing organic compounds, selective oxidation at carbon adjacent to aromatic systems, preparations of α,β-unsaturated carbonyl compounds and lactones, etc. These reactions take place in mild conditions, in high yields, and with high chemoselecticity. IBX-amide, IBX-ester and polymer-supported IBX analogues, which are mild, non-explosive, highly soluble, and/or recyclable, are also discussed.

Key words: organic synthesis, application, 2-iodoxybenzoic acid (IBX)