有机化学 ›› 2009, Vol. 29 ›› Issue (09): 1307-1316.    下一篇

综述与进展

三乙胺三(氟化氢)在有机合成中的应用

戴希杰 王亚平 赵圣印*   

  1. (东华大学化学化工与生物工程学院 上海 201620)
  • 收稿日期:2008-09-14 修回日期:2008-11-11 出版日期:2009-09-28 发布日期:2009-12-30
  • 通讯作者: 赵圣印

Advances in the Application of Triethylamine Tris(hydrofluoride) to Organic Synthesis

Dai, Xijie Wang, Yaping Zhao, Shengyin*   

  1. (College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620)
  • Received:2008-09-14 Revised:2008-11-11 Online:2009-09-28 Published:2009-12-30
  • Contact: Zhao, Shengyin

氟化反应在有机合成中有着广泛的应用, 三乙胺三(氟化氢)作为氟化试剂有着其它氟化试剂所无法比拟的优越性. 对近年来三乙胺三(氟化氢)在有机合成中的应用进行了总结和概述, 重点介绍了亲核取代、环氧开环反应、亲电加成反应和脱硅保护基等反应.

关键词: 三乙胺三(氟化氢), 有机合成, 应用, 氟化反应

Fluorination is widely used in organic synthesis. As a kind of fluorinating reagent, triethylamine tris(hydrofluoride) has the advantage on top of others. Several applications of triethylamine tris(hydrofluoride) to organic synthesis are summarized according to reaction type, especially for nucleophilic substitution, the ring-opening fluorination reaction of epoxide, electrophilic addition, desilylation reaction and so on.

Key words: organic synthesis, fluorination, application, triethylamine tris(hydrofluoride)