有机化学 ›› 2013, Vol. 33 ›› Issue (08): 1628-1646.DOI: 10.6023/cjoc201211039 上一篇    下一篇

综述与进展

铜催化C—H官能团化反应的研究进展

于海珠, 苏圣钦, 张弛, 党智敏   

  1. 北京科技大学高分子科学与工程系 北京 100083
  • 收稿日期:2012-11-21 修回日期:2013-02-18 出版日期:2013-08-25 发布日期:2013-03-14
  • 通讯作者: 党智敏 E-mail:dangzm@ustb.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21202006)和北京科技大学基本科研业务基金(No. FRF-TP-13-023A)资助项目.

Recent Progress in Copper Catalyzed C—H Functionalizations

Yu Haizhu, Su Shengqin, Zhang Chi, Dang Zhi-Min   

  1. Department of Polymer Science and Engineering, University of Science and Technology Beijing, Beijing 100083
  • Received:2012-11-21 Revised:2013-02-18 Online:2013-08-25 Published:2013-03-14
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21202006) and the Fundamental Research Funds for the Central Universities (No. FRF-TP-13-023A).

作为廉价、新型的C—H 官能团化反应催化剂, 铜络合物在多官能团有机物的制备中表现出良好的应用潜力. 系统总结了2008 年以来报道的铜催化C—H 官能团化反应, 其中分别阐述了一价及二价铜在sp, sp2及sp3 C—H 官能团化反应的研究进展, 在对反应条件、底物适用性等进行概括的基础上, 对各反应可能机理也进行也系统性归纳.

关键词: 铜催化, C—H官能团化, 偶联, 机理

The past decades have witnessed the great progress of copper-catalyzed C—H functionalization reactions, which have shown great potential in synthesizing multi-functionalized organic compounds. In the present review, the recent development of Cu(I)/Cu(II) catalyzed sp, sp2 and sp3 C—H bond functionalizations since 2008 is systematically summarized. Besides of the reaction conditions and substrate scopes for different C—H functionalizations, and the reported mechanistic studies were also summarized and discussed.

Key words: Cu catalysis, C—H functionalization, cross coupling, mechanism