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有机化学 2006, 26(04) 563-567 DOI:
ISSN: 0253-2786 CN: 31-1321/O6 |
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| 研究简报 |
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取代吲哚-3-甲醛类化合物的合成 |
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葛裕华*，吴亚明，薛忠俊 |
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(Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096) |
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摘要：
取代邻硝基甲苯(1)、N,N-二甲基甲酰胺二甲基缩醛或二乙基缩醛和哌啶在溶剂N,N-二甲基甲酰胺中缩合制得取代的β-哌啶基-2-硝基甲苯(2), 2用铁粉和冰醋酸还原环合得到取代吲哚(3), 将3与三氯氧磷和N,N-二甲基甲酰胺通过Vilsmeier-Hacck反应制得了取代吲哚-3-甲醛类化合物4和5. 化合物4和5的结构经元素分析, IR和1H NMR确认. |
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关键词：
取代吲哚-3-甲醛
合成
Vilsmeier-Hacck反应
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Synthesis of Substituted Indole-3-carboxaldehyde Derivatives |
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GE Yu-Hua*,WU Ya-Ming,XUE Zhong-Jun |
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Abstract:
Substituted 2-nitro-β-piperidinostyrenes (2), obtained from the reaction of substituted 2-nitrotoluene (1), N,N-dimethylformamide dimethyl acetal or N,N-dimethylformamide diethyl acetal and piperidine in solvent of N,N-dimethylformamide, reacted with iron and acetic acid to yield the substituted indoles 3. Substituted indole-3-carboxaldehydes 4 and 5 were synthesized from 3 by Vilsmeier-Hacck reaction with phosphorus oxychloride and N,N-dimethylformamide. The structures of 4 and 5 were analyzed and established by elemental analysis, IR and 1H NMR spectra. |
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Keywords:
substituted indole-3-carboxaldehyde
synthesis
Vilsmeier-Hacck reaction
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收稿日期 2005-06-08 修回日期 2005-10-31 网络版发布日期 |
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DOI: |
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基金项目:
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通讯作者: 葛裕华 |
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作者简介: |
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作者Email: |
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