(Department of Chemistry, Xinyang Normal University, Xinyang 464000)

Racemic diastereoisomeric spiro-phosphonate derivatives 5～6 were obtained by tandem double Michael addition and intramolecular nucleophilic substitution of 3-bromo-5-methoxy-5H-furan-2-one and α-hydroxylbenzylphosphonate under a warm condition. The target compounds 5～6 were identified by the elemental analysis, IR, 1H NMR, 13C NMR and MS techniques. The stereochemistry and configuration of 5c and 6c were confirmed further by X-ray crystallography. This result could lead to a new strategy for the synthesis of some complicated compounds containing a phosphorus functional group.