有机化学 ›› 2007, Vol. 27 ›› Issue (11): 1438-1440. 上一篇    下一篇

研究简报

8-烷基小檗碱的合成

杨勇a,b,叶小利c, 郑静a,d,张保顺a,李学刚*,a   

  1. (a西南大学药学院药用资源化学研究所 重庆 400716)
    (b怀化医学高等专科学校药学系 怀化 418000)
    (c西南大学生命科学学院 重庆 400716)
    (d西南大学化学化工学院 重庆 400716)
  • 收稿日期:2006-12-21 修回日期:2007-02-27 出版日期:2007-10-20 发布日期:2007-10-20
  • 通讯作者: 李学刚

Synthesis of 8-Alkylberberine

YANG Yonga,b,YE Xiao-Lic,ZHENG Jinga,d,ZHANG Bao-Shuna,LI Xue-Gang*,a   

  1. (a Chemistry Institute of Pharmaceutical Resources, School of Pharmaceutical Science, Southwest University,
    Chongqing 400716)
    (b Department of Pharmaceutical Science, Huaihua Medical College, Huaihua 418000)
    (c College of Life Science, Southwest University, Chongqing 400716)
    (d College of Chemistry and Chemical Engi-neering, Southwest University, Chongqing 400716)
  • Received:2006-12-21 Revised:2007-02-27 Online:2007-10-20 Published:2007-10-20
  • Contact: LI Xue-Gang

对比研究了乙醚、二氧六环和四氢呋喃(THF)三种溶剂对8位长链烷基取代小檗碱衍生物中间体合成产率的影响. 以四氢呋喃(THF)为反应溶剂, 8-癸基和8-月桂基盐酸小檗碱的产率是以乙醚为溶剂的4倍以上.

关键词: 8-烷基小檗碱, 合成, 溶剂效应

The effects of solvents ether (Et2O), dioxane and tetrahydrofuran on the yield of 8-alkyl substituted berberine derivates with long aliphatic chains were studied. Results showed that when tetrahydrofuran was used as a solvent, the yields of 8-decyl-, and 8-dodecyl-berberines were 4 times higher than those in ether.

Key words: synthesis, solvent effect, 8-alkyl substituted berberine derivate