有机化学 ›› 2000, Vol. 20 ›› Issue (5): 769-772. 上一篇    下一篇

研究论文

几个新型噁唑硼烷的制备与应用

荣国斌;李新明;张勇   

  1. 华东理工大学化学系.上海(200237)
  • 出版日期:2000-10-25 发布日期:2000-10-25

The preparation and application of two new types of oxazaborolidines

Rong Guobin;Li Xinming;Zhang Yong   

  1. East China Univ of Sci Tech., Dept Chem.Shanghai(200237)
  • Online:2000-10-25 Published:2000-10-25

以(1S,2S)-2-氨基-1-(4-硝基苯)-1,3-丙二醇为原料,得到四种噁唑硼烷,原? 淮呋鹜椴欢猿苹乖笆中苑蓟致哿朔从ξ露群痛呋两峁苟苑从峁挠跋臁? $601$ATwonewtypesof1,3,2-oxaborolidineswerepreparedfrom(1S,2S)-2-amino-1-(4-nitrophenyl)-propane-1,3-diolandusedascatalystsintheasymmetricreductionofacetophenone.Theinfluenceoftemperatureaswellastheeffectofthestructureofcatalystontheenantioselectivityisdiscussed.Theoriginoftheproducts'configurationalisexplored.

关键词: 噁唑, 硼杂环化合物, 恶唑硼烷, 不对称反应, 催化剂, 还原反应, 前手性酮, 硼烷类

Two new types of 1,3,2-oxaborolidines were prepared from (1S,2S)-2- amino-1-(4-nitrophenyl)-propane-1,3-diol and used as catalysts in the asymmetric reduction of acetophenone. The influence of temperature as well as the effect of the structure of catalyst on the enantioselectivity is discussed. The origin of the products' configurational is explored.

Key words: BORON HETEROCYCLIC COMPOUNDS, CATALYST, REDUCTION REACTION, BORANES

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