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β-取代卟啉 |
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光敏剂 |
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合成 |
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表征 |
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DNA切割 |
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黄齐茂 |
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李志远 |
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肖欣 |
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潘志权 |
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邓鹏星 |
| PubMed | |
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Article by Huang, J. M. |
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Article by Li, Z. Y. |
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Article by Xiao, X. |
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Article by Bo, Z. Q. |
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Article by Deng, F. X. |
以β-硝基卟啉为原料，分别与2,3-萘二酚或邻苯二酚直接反应，制备了6个新型β-二酚取代卟啉光敏药物，通过UV，1H NMR，IR，MS，元素分析等手段对化合物进行了结构表征并初步探讨了反应机理。DNA凝胶电泳实验表明，该类光敏剂对pBR322质粒DNA具有很好的光敏切割作用，作为光敏剂或其前体具有很好的应用前景.
Two kinds of novel β-dihydroxyarylporphyrins were synthesized by direct reaction of β-nitroporphyrin with 2,3-dihydroxynaphthalene and o-dihydroxybenzene respectively，and structurally characterized by UV，1H NMR，IR，MS and elemental analysis。The reaction mechanism was discussed。The agarose gel electrophoresis results show that the novel compounds cause significant cleavage to pBR322 plasmid DNA，which have good application prospects as photosensitizers or their precursors.
国家自然科学基金（批准号：20471045）; 湖北省自然科学基金青年杰出人才项目（批准号: 2008CDB072）;国家级.国家自然科学基金