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N3O2大环化合物 |
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合成 |
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小牛胸腺DNA |
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光谱 |
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陈稼轩 |
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田怡 |
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向清祥 |
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张丽群 |
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熊俊如 |
| PubMed | |
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Article by Chen, J. H. |
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Article by Tian, Y. |
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Article by Xiang, Q. X. |
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Article by Zhang, L. Q. |
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Article by Xiong, D. R. |
以8,11,14-三氮杂-5,6:16,17-二苯并-1,4-二氧杂环十七烷为原料，合成了含萘磺酰基的N3O2大环化合物，其结构经1H NMR，MS，元素分析等表征。通过紫外光谱法和荧光光谱法研究了N3O2大环化合物与小牛胸腺DNA的作用机制。结果表明: N3O2大环化合物通过嵌插方式与DNA结合，结合常数为 ＝20706.9 dm3•mol－1， ＝12416.9 dm3•mol－1，二者结合为焓驱动反应。
A N3O2-donor macrocycle bearing a naphathalic sulfonic group derived from 8,11,14-triaza-5,6: 16,17-dibenzo-1,4-dioxacycloheptadecane has been synthesized，and its structure was characterized by 1H NMR，MS data and elemental analysis。The interactions of the target compound with CT (calf thymus) DNA have been investigated by the ultraviolet spectrophotometry and fluorescence spectrophotometry。The results showed that the binding model between the N3O2-donor macrocycle and CT DNA was intercalation，with the binding constants being ＝20706.9 dm3•mol－1 and ＝12416.9 dm3•mol－1。The com-bination was the enthalpy driven reaction.
四川高校重点实验室专项（NO. 2006ZD049）;四川省教育厅（NO. 07ZC023）;乐山师范学院（NO. Z07045）项目