有机化学 ›› 2010, Vol. 30 ›› Issue (06): 833-836. 上一篇    下一篇

研究论文

2-甲基-3-(4-对甲氧基苯基)-5-(3-甲氧基苯基)异噁唑啉及其生物活性

程春生*,于萍,李志念,苏金燕,王鑫磊   

  1. 沈阳化工研究院 沈阳 110021
  • 收稿日期:2009-07-20 修回日期:2009-12-09 出版日期:2010-06-25 发布日期:2010-01-07
  • 通讯作者: 程春生 E-mail:chunshengcheng@163.com

2-Methyl-3-(4-methoxyphenyl)-5-(3-methoxyphenyl)isoxazoline and Its Bioactivity

CHENG Chun-Sheng, YU Ping, LI Zhi-Nian, SU Jin-Yan, WANG Xin-Lei   

  1. Shenyang Research Institute of Chemical Industry, Shenyang 110021
  • Received:2009-07-20 Revised:2009-12-09 Online:2010-06-25 Published:2010-01-07

采用1,3-偶极环加成反应合成了2-甲基-3-对甲氧基苯基-5-间甲氧基苯基异噁唑啉, 分离了顺、反异构体, 采用核磁共振氢谱分析表征了顺反异构体的谱图行为, 对异构体的生物活性进行了测定, 新杀菌剂2-甲基-3-对甲氧基苯 基-5-间甲氧基苯基异噁唑啉对病菌的有效成分为反式结构, 顺式体为无效成分.

关键词: 异噁唑啉, 核磁共振, 反式, 生物活性

2-Methyl-3-(4-methoxyphenyl)-5-(3-methoxyphenyl)isoxazoline was synthesized by 1,3-dipo- lar cycloaddition, and the Z and E isomers were separated. 1H NMR spectral analysis used to characterize the cis- and trans-isomers of the spectrum behavior. Their bioactivity shows that the E isomer is effective fungicide while Z isomer is ineffective.

Key words: isoxazoline, 1H NMR, E isomer, bioactivity