有机化学 ›› 2010, Vol. 30 ›› Issue (12): 1811-1819. 上一篇    下一篇

综述与进展

有机催化不对称Henry加成反应

高书涛1,郗国宏1李宁1,2王春1,马晶军*,1   

  1. (1河北农业大学理学院 河北省生物无机化学重点实验室 保定 071001)
    (2河北农业大学食品科技学院 保定 071001 )
  • 收稿日期:2009-06-22 修回日期:2010-02-07 出版日期:2010-12-20 发布日期:2010-06-10
  • 通讯作者: 马晶军 E-mail:majingjun@hebau.edu.cn
  • 基金资助:

    河北省自然科学基金(No 299158)和河北农业大学非生命学科和新兴学科科研发展基金资助项目

Organocatalytic Asymmetric Henry Reactions

Gao Shutao1 Xi Guohong1 Li Ning1,2 Wang Chun1 Ma Jing-jun*,1   

  1. (1 Hebei Key Laboratory of Bioinorganic Chemistry, College of Sciences, Agricultural Uni-versity of Hebei, Baoding 071001)
    (2 College of Food Science and Technology, Agricultural University of Hebei, Baoding 071001)
  • Received:2009-06-22 Revised:2010-02-07 Online:2010-12-20 Published:2010-06-10
  • Contact: Jing-Jun Ma E-mail:majingjun@hebau.edu.cn

有机催化不对称合成反应是目前国内外研究最为活跃的领域之一. 不对称Henry反应是合成光学活性硝基化合物的有效手段, 目前报道的催化不对称Henry反应的有机催化剂主要有手性胍、手性(硫)脲衍生物、金鸡纳碱衍生物等, 取得了良好的催化活性和对映选择性. 对各类有机催化剂在有机催化不对称Henry反应中的应用研究进展, 以及不对称诱导反应的机理、催化剂的分子结构及反应条件对其催化活性和不对称诱导活性的影响进行了评述.

关键词: 有机催化, 对映选择性, 不对称Henry反应

Organocatalytic asymmetric reaction is an increasingly active area in organic synthesis. Asymmetric Henry reaction is a versatile tool for the synthesis of chiral nitro compounds. The reported organocatalysts for asymmetric Henry reaction include chiral guanidines, chiral (thio)urea derivatives, cinchona alkaloids and so on, which could catalyze the asymmetric Henry reaction with high catalytic activity and excellent enantioselectivity. The applications of various organocatalysts in asymmetric Henry reaction are reviewed in this paper. The reaction mechanism, catalytic activity and the asymmetric induction influenced by the structure of organocatalysts and the reaction conditions are also discussed.

Key words: organocatalysis, enantioselectivity, asymmetric Henry reaction