有机化学 ›› 2011, Vol. 31 ›› Issue (08): 1272-1276. 上一篇    下一篇

研究简报

微波促进下无溶剂一锅法合成含氟喹唑啉-4(3H)-酮类化合物

商文丽,章建民*,金见安,陈晓蕾   

  1. (上海大学理学院化学系 上海 200444)
  • 收稿日期:2010-10-21 修回日期:2011-01-19 出版日期:2011-08-25 发布日期:2011-03-14
  • 通讯作者: 章建民 E-mail:jmzhang@shu.edu.cn;

One-Pot Preparation of Fluorinated 4(3H)-Quinazolinones under Microwave Irradiation and Solvent-Free Conditions

SHANG Wen-Li, ZHANG Jian-Min, JIN Jian-An, CHEN Xiao-Lei   

  1. (Department of Chemistry, School of Science, Shanghai University, Shanghai 200444)
  • Received:2010-10-21 Revised:2011-01-19 Online:2011-08-25 Published:2011-03-14

采用邻胺基苯甲酸、原甲酸三乙酯及含氟苯胺为原料, 在微波促进下, 无溶剂一锅法高效合成了系列3-氟苯基-喹唑啉-4(3H)-酮类化合物, 同时测试了新化合物的荧光性能, 并与不含氟同类化合物的荧光发射光谱进行了比较.

关键词: 含氟喹唑啉酮, 微波促进, 一锅法, 无溶剂法, 荧光发射光谱

A facile one-pot method has been developed for the synthesis of ?uorine-containing 4(3H)-quinazolinones by a three-component coupling of anthranilic acid, triethyl orthoformate and ?uorinated anilines under microwave irradiation and solvent-free conditions. All new compounds are fully characterized by spectral methods, especially, fluorescence.

Key words: fluorinated 4(3H)-quinazolinones, microwave, one-pot reaction, solvent free, fluorescence emission spectrum