有机化学 ›› 2012, Vol. 32 ›› Issue (04): 641-650.DOI: 10.6023/cjoc1107172 上一篇    下一篇

综述与进展

光学纯的2-羟基-4-苯基丁酸乙酯的合成进展

诸吕锋a, 陈厚和a, 孟庆华b, 谢小敏b, 李月刚c, 张兆国b   

  1. a 南京理工大学化工学院 南京 210094;
    b 上海交通大学化学化工学院 上海 200240;
    c 中化国际(苏州)新材料研发有限公司 苏州 215433
  • 收稿日期:2011-07-17 修回日期:2011-10-27 出版日期:2012-04-25 发布日期:2012-04-24
  • 通讯作者: 张兆国 E-mail:zhaoguo@sjtu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 20872090)资助项目.

Progress in the Synthesis of Optically Pure Ethyl 2-Hydroxy-4-phenylbutyrate

Zhu Lvfenga, Chen Houhea, Meng Qinghuab, Xie Xiaominb, Li Yuegangc, Zhang Zhaoguob   

  1. a School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094;
    b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240;
    c Sinochem International (Suzhou) New Material R&D Co., Ltd, Suzhou 215433
  • Received:2011-07-17 Revised:2011-10-27 Online:2012-04-25 Published:2012-04-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20872090).

(R)-2-羟基-4-苯基丁酸乙酯是血管紧张素转化酶抑制剂类(ACEI)药物的重要中间体. 综述了其合成方法, 重点介绍了最新的高效合成方法的研究进展.

关键词: (R)-2-羟基-4-苯基丁酸乙酯, 血管紧张素转化酶抑制剂, 不对称氢化, 酶,

(R)-2-Hydroxy-4-phenylbutyrate is a key intermediate for the synthesis of angiotensin-converting enzyme inhibitors (ACEI). The review will cover its synthetic methods, and mainly focus on the recent progress in efficient synthesis.

Key words: ethyl (R)-2-hydroxy-4-phenylbutyrate, angiotensin-converting enzyme inhibitor, asymmetric hydrogenation, enzyme, ruthenium