有机化学 ›› 2012, Vol. 32 ›› Issue (04): 727-731.DOI: 10.6023/cjoc1107022 上一篇    下一篇

研究论文

两个新的化合物线四肽和单羟基甾醇的分离与结构鉴定

王长军, 梁远维, 廖小建, 徐石海   

  1. 暨南大学化学系 广州 510632
  • 收稿日期:2011-07-02 修回日期:2011-11-01 出版日期:2012-04-25 发布日期:2012-04-24
  • 通讯作者: 徐石海 E-mail:txush@jnu.edu.cn
  • 基金资助:

    国家863 基金(No. 2006AA09Z408)、国家自然科学基金(Nos. 20772048, 21172094)和广东省科技计划(No. 211A080504007)资助项目.

Isolation and Identification of Two New Compounds Linear Tetrapeptide and Monohydroxysteroid

Wang Changjun, Liang Yuanwei, Liao Xiaojian, Xu Shihai   

  1. Department of Chemistry, Jinan University, Guangzhou 510632
  • Received:2011-07-02 Revised:2011-11-01 Online:2012-04-25 Published:2012-04-24
  • Supported by:

    Project supported by the National High Technology Development Project (No. 2006AA09Z408), the National Natural Science Foundation of China (Nos. 20772048, 21172094) and the Science and Technology Plan Project of Foundation Guangdong Province (No. 21172094).

采用现代分离手段, 从采自中国南海硇洲岛的白穗软珊瑚Nephthea sp.中分离纯化得到两个新的化合物分别为线四肽化合物和单羟基甾醇, 经过MS, 1H NMR, 13C NMR (DEPT), HSQC, HMBC 和NOE 等光谱技术鉴定它们的结构为: 亮氨酰-N-甲基亮氨酰-亮氨酰-N-甲基亮氨酸(1)和(20S,22R)-孕甾-1,4-二烯-22-乙酰基-3-酮(2), 这两个化合物均为新化合物. 肿瘤活性实验表明两个新的化合物显示微弱的细胞毒性.

关键词: 软珊瑚, Nephthea sp., 线四肽, 单羟基甾醇

Two new compounds have been isolated from Nephthea sp. collected from Naozhou Islands of the South China Sea. Their structures were established as leucyl-N-methyl-leucyl-leucyl-N-methyl-leucine (1), (20S,22R)-progesterone-1,4- diene-22-acetyl-3-one (2) by MS, IR, 1H NMR, 13C NMR (DEPT), HSQC, HMBC and NOE analysis. Both of them are previously unknown compounds and showed weak cytotoxicity against the cancer cell lines.

Key words: coral, Nephthea sp., linear tetrapeptide, monohydroxysteroid