有机化学 ›› 2012, Vol. 32 ›› Issue (04): 732-741.DOI: 10.6023/cjoc1108302 上一篇    下一篇

研究论文

无催化剂微波促进下C—O, C—N 和C—S 交叉偶联反应研究

袁艳琴, 郭圣荣, 莫建军, 钱利, 石泽凤   

  1. 丽水学院化学化工系 丽水 323000
  • 收稿日期:2011-08-30 修回日期:2011-11-03 出版日期:2012-04-25 发布日期:2012-04-24
  • 通讯作者: 郭圣荣 E-mail:guosr9609@lsu.edu.cn
  • 基金资助:

    浙江省自然科学基金基金(No. Y407240)和丽水学院重点科研(No. KZ20H03)资助项目.

Rapid and Highly Efficient Microwave-Assisted C—N, C—O and C— S Coupling Reactions without a Transition-Metal Catalyst

Yuan Yanqin, Guo Shengrong, Mo Jianjun, Qian Li, Shi Zefeng   

  1. Department of Chemistry, Lishui University, Lishui 323000
  • Received:2011-08-30 Revised:2011-11-03 Online:2012-04-25 Published:2012-04-24
  • Supported by:

    Project supported by the Natural Science Foundation of Zhejiang Province (No. Y407240) and the Key Science Foundation of Lishui University (No. KZ20H03).

在无金属催化剂的条件下, 利用微波加热促进C—O, C—N 和C—S 交叉偶联反应. 实验发现以DMSO 为溶剂,t-BuOK 为碱, 利用微波加热, 活化的氯代芳烃能与各类亲核试剂顺利反应, 得到中等及优良的产率.

关键词: 微波, 交叉偶联反应, 芳基醚, 芳基硫醚, N-芳基化

A rapid and direct coupling reactions of various N/O/S nucleophilic reagents with aryl halides have been developed in good to high yields under microwave irradiation without a transition-metal catalyst. These reactions are a particularly powerful method for the coupling of electron-withdraw aryl halides with various nucleophilic reagents. A variety of products including aryl ethers, N-arylamides, and aryl thioethers were synthesized in good to excellent yields.

Key words: microwave, cross-coupling reactions, aryl ethers, aryl thioethers, N-arylation