有机化学 ›› 2013, Vol. 33 ›› Issue (08): 1595-1615.DOI: 10.6023/cjoc201303038 上一篇    下一篇

综述与进展

3-羟基氧化吲哚的不对称合成:金属催化和有机催化

刘运林, 朱锋, 王翠红, 周剑   

  1. 华东师范大学化学系 绿色化学与化工过程绿色化上海市重点实验室 上海 200062
  • 收稿日期:2013-03-24 修回日期:2013-04-13 出版日期:2013-08-25 发布日期:2013-04-24
  • 通讯作者: 周剑 E-mail:jzhou@chem.ecnu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 20902025, 21172075);国家重点基础研究发展计划(973计划, No. 2011CB808600);教育部新世纪优秀人才计划(No. NCET-11-0147);教育部博士新人奖(No. MXRZZ2012007)资助项目.

Metal Catalysis versus Organocatalysis in the Catalytic Asymmetric Synthesis of 3-Hydroxyoxindole

Liu Yunlin, Zhu Feng, Wang Cuihong, Zhou Jian   

  1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062
  • Received:2013-03-24 Revised:2013-04-13 Online:2013-08-25 Published:2013-04-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20902025, 21172075), the National Basic Research Program of China (973 Program, No. 2011CB808600), the Program for New Century Excellent Talents in University (No. NCET-11-0147), the Scholarship Award for Excellent Doctoral Student Granted by Ministry of Education (No. MXRZZ2012007).

3-取代的3-羟基氧化吲哚广泛存在于天然产物和药物活性分子中, 是一类受到合成化学家广泛关注的优势骨架. 近年来, 围绕这一骨架的不对称催化合成取得了很大的进展. 本综述旨在介绍几类重要的3-羟基氧化吲哚结构单元的不对称催化合成方法, 藉此讨论有机催化和金属催化这两种不同催化模式各自的一些特点和优势之处.

关键词: 3-取代的3-羟基氧化吲哚, 不对称催化, 金属催化, 有机催化

3-Substituted 3-hydroxyoxindoles are widely encountered in a large number of natural products, drugs and pharmaceutically active compounds. The catalytic asymmetric construction of this privileged skeleton has attracted great attention from synthetic chemistry, and much progress has been made in recent years. This review summarizes the advances in the catalytic enantioselective synthesis of four important types of subunits of 3-substituted 3-hydroxyoxindoles, and focuses on the discussion of the differences and advantages of metal catalysis and organocatalysis.

Key words: 3-substituted-3-hydroxyoxindole, asymmetric catalysis, metal catalysis, organocatalysis