有机化学 ›› 2014, Vol. 34 ›› Issue (2): 292-303.DOI: 10.6023/cjoc201309008 上一篇    下一篇

综述与进展

磷手性中心的不对称构建

姚秋丽a, 王安俊a, 蒲家志b, 唐瑜敏b   

  1. a 遵义医学院药学院 遵义 563003;
    b 遵义医学院国有资产管理处 遵义 563003
  • 收稿日期:2013-09-04 修回日期:2013-10-10 出版日期:2014-02-25 发布日期:2013-10-31
  • 通讯作者: 姚秋丽 E-mail:yaoqiuli@zmc.edu.cn

Enantioselective Synthesis of P-Stereogenic Compounds

Yao Qiulia, Wang Anjuna, Pu Jiazhib, Tang Yuminb   

  1. a School of Pharmacy, Zunyi Medical College, Zunyi 563003;
    b State-owned Assets Management Department, Zunyi Medical College, Zunyi 563003
  • Received:2013-09-04 Revised:2013-10-10 Online:2014-02-25 Published:2013-10-31

对由非光学活性底物不对称构建磷手性中心的方法进行综述,根据底物的结构以及机理的不同分为两类介绍,分别是前对映异构体的去对称化以及不同取代底物的化学拆分.

关键词: 手性磷化物, 不对称合成, 手性拆分

Methods for enantioselective synthesis of P-stereogenic compounds from non-optically active substrates are reviewed. Two stategies can be classified according to the substrates and mechanisms of their reactions, which include enantioselective desymmetrisations and chemical resolutions.

Key words: P-stereogenic compound, asymmetric synthesis, chiral resolution