有机化学 ›› 2014, Vol. 34 ›› Issue (4): 706-716.DOI: 10.6023/cjoc201310015 上一篇    下一篇

综述与进展

氨基葡萄糖衍生物配体在不对称合成中的应用进展

宋沙沙, 周宏勇, 李小娜, 王丽华, 李云庆, 王家喜   

  1. 河北工业大学化工学院 天津 300130
  • 收稿日期:2013-10-14 修回日期:2013-12-05 出版日期:2014-04-25 发布日期:2013-12-13
  • 通讯作者: 王家喜 E-mail:wangjiaxi@hebut.edu.cn
  • 基金资助:

    河北省自然科学基金(No. B2011202087)资助项目

Advance of Glucosamine and Their Derivatives as Chiral Ligands in Asymmetric Syntheses

Song Shasha, Zhou Hongyong, Li Xiaona, Wang Lihua, Li Yunqing, Wang Jiaxi   

  1. School of Chemical Engineering, Hebei University of Technology, Tianjin 300130
  • Received:2013-10-14 Revised:2013-12-05 Online:2014-04-25 Published:2013-12-13
  • Supported by:

    Project supported by the Natural Science Foundation of Hebei Province (No. B2011202087)

氨基葡萄糖是广泛存在于自然界的手性天然产物壳聚糖的降解产物,多手性中心及强的配位能力使之成为制备手性胺基、胺基/膦基配体的理想原料. 氨基葡萄糖衍生物作为手性配体参与的不对称反应已成为有机化学中非常活跃的研究领域. 综述了氨基葡萄糖衍生物在不对称烯丙基烷基化、Heck反应、1,4-共轭加成反应、烯烃的环氧化反应、烯烃环丙化等反应的最新研究进展.

关键词: 手性配体, 氨基葡萄糖, 金属络合物, 不对称合成

Glucosamine is a chiral compound degraded from widely existed natural product chitosan. It is becoming an ideal raw material for preparation chiral amine, amine/phosphine ligands due to its more chiral centers and strong coordination ability. The application of glucosamine derivatives as chiral ligands in asymmetric organic reactions has become a very active research area. In this paper, the application of glucosamine derivatives in asymmetric allylic alkylation, Heck reaction, 1,4-conjugate addition reaction, epoxidation reaction of olefins and cyclopropanation of olefin has been reviewed.

Key words: chiral ligand, glucosamine, metal complex, asymmetric synthesis