有机化学 ›› 2014, Vol. 34 ›› Issue (4): 722-728.DOI: 10.6023/cjoc201310045 上一篇    下一篇

研究论文

2-取代-6-甲基-4-苯基-3(2H)-哒嗪酮类化合物的合成及除草活性研究

许寒a,d, 战明哲b, 刘斌c, 杨华铮c   

  1. a 南开大学农药国家工程研究中心 天津 300071;
    b 郑州大学化学与分子工程学院 郑州 450001;
    c 南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071;
    d 天津化学化工协同创新中心 天津 300071
  • 收稿日期:2013-10-28 修回日期:2013-12-16 出版日期:2014-04-25 发布日期:2014-01-02
  • 通讯作者: 许寒 E-mail:xuhan@nankai.eu.cn
  • 基金资助:

    国家自然科学基金(No. 21002054)、高等学校博士学科点专项科研基金(No. 20100031120016)和中央高校基本科研业务费资助项目.

Synthesis and Herbicidal Activity of 2-Substituted-6-methyl-4-phenyl-3(2H)-pyridazinone

Xu Hana,d, Zhan Mingzheb, Liu Binc, Yang Huazhengc   

  1. a National Pesticidal Engineering Centre (Tianjin), Nankai University, Tianjin 300071;
    b College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001;
    c State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071;
    d Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071
  • Received:2013-10-28 Revised:2013-12-16 Online:2014-04-25 Published:2014-01-02
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21002054), the Research Fund for the Doctoral Programme of Higher Education (No. 20100031120016) and the Fundamental Research Funds for the Central Universities.

设计合成了一系列文献中未报道的2-取代-6-甲基-4-苯基-3(2H)-哒嗪酮类化合物,其结构经过1H NMR和元素分析确证,化合物4e进行了X 射线衍射晶体结构分析. 利用油菜平皿法和稗草小杯法对化合物进行了生物活性的测定. 初步生物活性测试结果表明,化合物4具有较好的除草活性. 定量构效关系表明,化合物4结构中哒嗪环2-位取代基的变化,影响了化合物的抑制活性. 当作用对象为油菜时,化合物的活性可能主要与取代基R的立体参数B4和疏水性有关;当作用对象为稗草时,化合物的活性可能主要与取代基R的疏水性有关. 部分化合物4的抑制活性与对照药品5b5k基本相当,但没有表现出5b5k所具有的白化效果. 化合物45这两类结构类似的化合物很可能在生物体内拥有不同的作用机制.

关键词: 苯基哒嗪酮, 除草活性, 定量结构与活性关系

A series of novel 2-substituted-6-methyl-4-phenyl-3(2H)-pyridazinone derivatives were synthesized. All target compounds were structurally confirmed by 1H NMR and elemental analysis. An X-ray crystallographic structure determination was carried out in compound 4e. Herbicidal activities were evaluated through Brassica napus and Echinochloa crusgalli (L.) Beauv tests. Bioassay results showed that most of compounds exhibited better herbicidal activities. Quantitative structure-activity relationship studies showed that when the test grass was rape, their herbicidal activity was mainly related with substituent's sterimol parameter B4 and hydrophobic parameter π; when the test grass was barnyard grass, their herbicidal activity was mainly related with the hydrophobic parameter π of the substituents at the 2-position of pyridazinone ring. Some compounds 4 showed inhibitive activity equal to 5b and 5k, but showed no bleaching activity. The action mode in plants may be different in compounds 4 and 5.

Key words: phenylpyridazinone, herbicidal activity, quantitative structure-activity relationship