有机化学 ›› 2014, Vol. 34 ›› Issue (8): 1673-1676.DOI: 10.6023/cjoc201403016 上一篇    下一篇

研究简报

乙酰乙酰芳胺类化合物导向的五取代1,4-二氢吡啶衍生物的合成

陈翠, 谭丽泉, 邱会华   

  1. 广东石油化工学院化学工程学院 茂名 525000
  • 收稿日期:2014-03-07 修回日期:2014-04-02 出版日期:2014-08-25 发布日期:2014-04-18
  • 通讯作者: 陈翠 E-mail:cc161002@gmail.com
  • 基金资助:
    广东省自然科学基金(No.S2012040007868)资助项目.

Synthesis of Multi-substituted 1,4-Dihydropyridine Derivatives from Acetoacetanilides

Chen Cui, Tan Liquan, Qiu Huihua   

  1. College of Chemcal Engineering, Guangdong University of Petrochemical Technology, Maoming 525000
  • Received:2014-03-07 Revised:2014-04-02 Online:2014-08-25 Published:2014-04-18
  • Supported by:
    Project supported by the Natural Science Foundation of Guangdong Province (No. S2012040007868).

以乙酰乙酰芳胺类化合物类化合物为原料,醋酸为溶剂,过硫酸铵[(NH42S2O4]为氧化剂,通过三组分缩合,成功地构建出了五取代1.4-二氢吡啶类衍生物. 其结构经IR,1H NMR,13C NMR和HR-MS得到了确认,并提出了可能的反应机理.

关键词: 过硫酸铵, 分子间缩合, 1.4-二氢吡啶类衍生物, 乙酰乙酰苯胺类化合物

This paper reports a simple intermolecular condensation reaction for the synthesis of 1,4-dihydropyridine derivatives from acetoacetanilides using AcOH as the solvent and ammonium persulfate[(NH4)2S2O4] as the oxidant. The structures of products were confirmed by IR, 1H NMR, 13C NMR and HR-MS. In addition, a possible reaction mechanism was proposed.

Key words: ammonium persulfate, intermolecular condensation, 1,4-dihydropyridine derivatives, acetoacetanilides