有机化学 ›› 2014, Vol. 34 ›› Issue (8): 1588-1594.DOI: 10.6023/cjoc201402040 上一篇    下一篇

研究论文

锌粉促进三组分“一锅法”合成新型氨基甲酸酯

孟团结, 刘澜涛, 任利锋, 刘新明, 王晓娟, 赵文献   

  1. 商丘师范学院化学化工学院 有机新材料合成重点实验室 商丘 476000
  • 收稿日期:2014-02-28 修回日期:2014-04-28 出版日期:2014-08-25 发布日期:2014-05-05
  • 通讯作者: 刘澜涛,赵文献 E-mail:liult05@iccas.ac.cn,zhwx5126@gmail.com
  • 基金资助:

    国家自然科学基金(No.U1204204)和商丘师范学院青年基金(No.2011QN17)资助项目.

One-Pot Three-Component Synthesis of Novel Carbamate Compounds Mediated by Zinc Powder

Meng Tuanjie, Liu Lantao, Ren Lifeng, Liu Xinming, Wang Xiaojuan, Zhao Wenxian   

  1. Key Laboratory of New Organic Materials Synthesis, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000
  • Received:2014-02-28 Revised:2014-04-28 Online:2014-08-25 Published:2014-05-05
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. U1204204) and the Youth Foundation of Shangqiu Normal University (No. 2011QN17).

在金属锌的促进下,以醛、溴代烃和异氰酸酯为原料,THF为溶剂,室温、非催化条件下,通过三组分“一锅法”反应合成了一系列新型的氨基甲酸酯类化合物. 该方法具有反应条件温和、操作简单、产率高、原料易得、反应迅速的特点. 通过1H NMR,13C NMR,IR,HRMS和元素分析对产物结构进行了表征.

关键词: 氨基甲酸酯, 锌粉, 一锅法, 三组分, 合成

A series of novel carbamate compounds were obtained from one pot three component reaction of aldehydes, bromohydrocarbons and isocyanates mediated by zinc powder under room temperature. This protocol has advantages of mild conditions, simple work-up, high yield, easily available starting materials and fast reaction rate. The structures of all products were characterized by 1H NMR, 13C NMR, IR, HRMS and elemental analysis.

Key words: carbamate compounds, zinc powder, one-pot, three-component, synthesis