有机化学 ›› 2014, Vol. 34 ›› Issue (9): 1895-1899.DOI: 10.6023/cjoc201404009 上一篇    下一篇

研究简报

无催化剂条件下有效的四组分反应合成2,3-二氢噻吩衍生物

张金鹏b, 高亚年a, 陈明a, 姜灵a, 夏盛a, 荣良策a   

  1. a 江苏师范大学化学化工学院, 徐州 221116;
    b 徐州医学院公共卫生学院, 徐州 221004
  • 收稿日期:2014-04-03 修回日期:2014-04-29 出版日期:2014-09-25 发布日期:2014-05-07
  • 通讯作者: 荣良策 E-mail:lcrong@jsnu.edu.cn; lcrong2005@yahoo.com
  • 基金资助:

    国家自然科学基础研究基金(No. 21172188)和江苏省功能性材料绿色合成重点实验室开放课题(No. K201312)资助项目.

An Efficient Synthesis of 2,3-Dihydrothiophene Derivatives from Four-Component Reactions under Catalyst-Free Conditions

Zhang Jinpengb, Gao Yaniana, Chen Minga, Jiang Linga, Xia Shenga, Rong Liangcea   

  1. a School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116;
    b Department of Public Health, Xuzhou Medical College, Xuzhou 221004
  • Received:2014-04-03 Revised:2014-04-29 Online:2014-09-25 Published:2014-05-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172188), and the Open Foundation of Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials (No. K201312).

芳香醛、2,4-噻唑烷二酮、丙二腈和3-吡啶甲胺于95%乙醇中四组分反应,方便地获得一系列新的2,3-二氢噻吩衍生物. 这是杂环胺类化合物首次应用于噻吩衍生物的合成,具有反应条件温和、容易操作、产率高等优点. 产物的结构经过红外、核磁和高分辨质谱确定.

关键词: 噻吩, 2,4-噻唑烷二酮, 3-吡啶甲胺, 四组分反应

An efficient synthesis of 2,3-dihydrothiophene derivatives by the four-component reactions of aromatic aldehydes, thiazolidine-2,4-dione, malononitrile and pyridin-3-ylmethanamine has been reported. This reaction could be carried out smoothly without using any other catalysts in ethanol (95%) and the aromatic heterocyclic amine (pyridin-3-ylmethanamine) was first used for the synthesis of 2,3-dihydrothiophene derivatives. The advantages of this procure were mild reaction conditions, easy operation, and high yields. The products were identified by IR, 1H NMR and HRMS.

Key words: thiophene, thiazolidine-2,4-dione, pyridin-3-ylmethanamine, four-component reactions