有机化学 ›› 2015, Vol. 35 ›› Issue (1): 228-231.DOI: 10.6023/cjoc201407003 上一篇    下一篇

研究简报

钯催化2-羟基苯基二茂铁乙烯的合成

刘世娟, 马文兵, 郑志花, 马忠平, 曹端林   

  1. 中北大学化工与环境学院 太原 030051
  • 收稿日期:2014-07-02 修回日期:2014-09-03 出版日期:2015-01-25 发布日期:2014-09-18
  • 通讯作者: 马文兵, 曹端林 E-mail:mawenbing@nuc.edu.cn;cdl@nuc.edu.cn

Palladium-Catalyzed Synthesis of 2-Hydroxyphenyl Vinylferrocene

Liu Shijuan, Ma Wenbing, Zheng Zhihua, Ma Zhongping, Cao Duanlin   

  1. School of Chemical and Environmental Engineering, North University of China, Taiyuan 030051
  • Received:2014-07-02 Revised:2014-09-03 Online:2015-01-25 Published:2014-09-18

以Pd为催化剂, 实现二茂铁乙烯与邻碘(溴)苯酚化合物的交叉偶联, 考察了钯催化剂种类、碱的种类、溶剂等因素对反应的影响. 结果表明, 在PdCl2(dppf)为催化剂, 用量为5 mol%, Cs2CO3为碱, CH3CN为溶剂的条件下, 可高效率高产率地得到一系列邻羟基二茂铁茋类化合物.

关键词: Heck偶联反应, 二茂铁乙烯, 邻碘(溴)苯酚, 钯催化

A Pd-catalyzed method was developed for Heck-type cross-coupling reaction of a wide range of o-iodo(bromo)- phenols with vinylferrocene. The influences of different palladium catalyst, bases, solvents and other conditions were investigated. In the presence of PdCl2(dppf), Cs2CO3 and CH3CN, the cross-coupling products can be obtained in moderate to good yields. This catalyst system exhibits good activity in the synthesis of o-hydroxyphenyl vinylferrocene compounds.

Key words: Heck-type cross-coupling reaction, vinylferrocene, o-iodo(bromo)phenols, palladium-catalyzed