有机化学 ›› 2015, Vol. 35 ›› Issue (9): 1991-1993.DOI: 10.6023/cjoc201504041 上一篇    下一篇

研究简报

铝盐促进的谷氨酸转氨化合成α-酮戊二酸的研究

吴江, 黄少胥   

  1. 中国科学院上海有机化学研究所 上海 200032
  • 收稿日期:2015-04-27 修回日期:2015-05-11 出版日期:2015-09-25 发布日期:2015-05-15
  • 通讯作者: 黄少胥 E-mail:hsx@sioc.ac.cn
  • 基金资助:

    上海市自然科学基金(No. 13ZR1464900)资助项目.

Aluminum(III) Salts Promoted Transamination of Glutamic Acid for the Synthesis of α-Ketoglutaric Acid

Wu Jiang, Huang Shao-Xu   

  1. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2015-04-27 Revised:2015-05-11 Online:2015-09-25 Published:2015-05-15
  • Supported by:

    Project supported by the Natural Science Foundation of Shanghai City (No. 13ZR1464900).

报道了以铝盐为促进剂、通过对谷氨酸向乙醛酸水合物转氨化合成α-酮戊二酸的简便方法. 通过对反应条件的系统优化, 发现在少量简单铝盐KAl(SO4)2·12H2O存在下, 在pH=5的水溶液中, 80 ℃下反应4 h, 能够方便地实现谷氨酸向乙醛酸的高效转氨化, α-酮戊二酸收率最高可达到87%. 该方法原料价廉易得、操作简便、产率优良、提供了一种α-酮戊二酸的高效、实用合成方法.

关键词: 谷氨酸, α-酮戊二酸, 转氨化

This paper reports an efficient approach for the synthesis of α-ketoglutaric acid via Al(III) salt promoted transamination of glyoxylic acid monohydrate with glutamic acid. Under optimized conditions (80 ℃, pH=5), the transamination proceeded efficiently in an aqueous solution of glyoxylic acid and glutamic acid in the presence of a catalytic amount of KAl(SO4)2·12H2O, affording α-ketoglutaric acid in up to 87% yield. This method features inexpensive chemical feedstocks, easy operation and high productivity, thus providing an efficient and practical approach to α-ketoglutaric acid.

Key words: glutamic acid, α-ketoglutaric acid, transamination