有机化学 ›› 2015, Vol. 35 ›› Issue (8): 1650-1656.DOI: 10.6023/cjoc201502022 上一篇    下一篇

研究论文

纳米钯催化的高效Suzuki偶联反应

赵晓霞a, 常宏宏b, 李兴b, 魏文珑b   

  1. a 太原科技大学化学与生物工程学院 太原 030021;
    b 太原理工大学化学化工学院 太原 030024
  • 收稿日期:2015-02-14 修回日期:2015-06-04 出版日期:2015-08-25 发布日期:2015-06-12
  • 通讯作者: 赵晓霞 E-mail:kdhyzxx@163.com
  • 基金资助:

    山西省自然科学基金(No. 2012021007-2)资助项目.

Nanoparticles Pd-Catalyzed Highly Efficient Suzuki Cross-Coupling Reaction

Zhao Xiaoxiaa, Chang Honghongb, Li Xingb, Wei Wenlongb   

  1. a College of Chemistry and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan 030021;
    b College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024
  • Received:2015-02-14 Revised:2015-06-04 Online:2015-08-25 Published:2015-06-12
  • Supported by:

    Project supported by the Natural Science Foundation of Shanxi Province (No. 2012021007-2).

开发了一种使用Al2O3作载体, 由四三苯基膦钯制备的纳米钯催化剂催化的高效绿色Suzuki 反应来合成联苯类化合物的方法. 该反应体系以DMF和H2O的混合体系作反应溶剂, 在空气中于25~90 ℃下, 催化剂可高效催化卤代芳烃与芳基硼酸的Suzuki偶联反应, 所有考察的反应底物都给出很高的收率, 并且催化剂循环利用6次后, 其催化活性和反应收率都没有明显降低.

关键词: 纳米钯, Suzuki 反应, Pd/Al2O3, 联苯类化合物,

An efficient protocol for the Suzuki reactions catalyzed by Pd(PPh3)4-derived nanoparticles palladium catalyst has been developed. This method is able to prepare a variety of biaryls under air atmosphere at 25~90 ℃ in DMF/H2O mixture solvent. In the presence of this catalyst, the cross-coupling reactions of aryl halides with arylboronic acids proceed smoothly and afforded the desired coupling products with high yields. The catalyst could be recycled 6 times without loss of activity and decrease of yield.

Key words: nanoparticles palladium, Suzuki reaction, Pd/Al2O3, biphenyls, H2O