有机化学 ›› 2016, Vol. 36 ›› Issue (2): 393-398.DOI: 10.6023/cjoc201509011 上一篇    下一篇

研究简报

1-(吡啶-2-基)-2-芳氧基-2-(α-1H-1,2,4-三唑-1-基)乙酮的合成、晶体结构与生物活性

戴红a,b, 刘建兵a, 陶伟峰a, 苗文科a, 方建新a, 汪清民a   

  1. a 南开大学元素有机化学国家重点实验室 天津 300071;
    b 南通大学化学化工学院 南通 226019
  • 收稿日期:2015-09-08 修回日期:2015-09-30 出版日期:2016-02-25 发布日期:2015-11-03
  • 通讯作者: 戴红, 方建新 E-mail:daihong_2001@aliyun.com;yssfjx@yahoo.com.cn
  • 基金资助:

    国家自然科学基金(Nos. 20772068)、元素有机化学国家重点实验室开放课题(No. 201412)和南通市科技计划(Nos. CP12013002, AS2014011)资助项目

Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones

Dai Honga,b, Liu Jianbinga, Tao Weifenga, Miao Wenkea, Fang Jianxina, Wang Qingmina   

  1. a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
  • Received:2015-09-08 Revised:2015-09-30 Online:2016-02-25 Published:2015-11-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20772068), the Open Project Fund of State Key Laboratory of Elemento-organic Chemistry (No. 201412), and the Science and Technology Project Fund of Nantong City (Nos. CP12013002, AS2014011)

为了从三唑类化合物中寻找新的活性化合物, 采用活性亚结构拼接和活性叠加方法, 将吡啶环结构单元引入到三唑类化合物分子中, 制备了一系列未见文献报道的新型含吡啶环结构的三唑类衍生物. 经1H NMR, 13C NMR, IR, MS和元素分析对所合成的化合物的结构进行了表征. 此外, 采用X射线单晶衍射分析方法进一步测定了化合物4k的晶体结构. 初步的生物活性测试表明, 部分目标化合物在试验浓度下具有一定的杀菌和植物生长调节活性.

关键词: 三氮唑, 吡啶环, 合成, 生物活性

In order to find novel triazole lead compounds, a series of new triazole derivatives containing pyridine moiety were synthesized by the introduction of the important pyridyl backbone into the molecules of triazoles. They were structurally confirmed by 1H NMR, 13C NMR, IR, MS and elemental analysis. Additionally, compound 4k was structurally characterized through X-ray single crystal diffraction method. Preliminary bioassay data showed that some of the title compounds displayed moderate fungicidal and plant growth regulatory activities.

Key words: triazole, pyridine, synthesis, bioactivity