有机化学 ›› 2016, Vol. 36 ›› Issue (1): 113-120.DOI: 10.6023/cjoc201507017 上一篇    下一篇

研究论文

无溶剂研磨法快速合成3-芳乙烯基-1,5-二酮类化合物的反应研究

王克虎, 殷雪娇, 陶瑞, 黄丹凤, 苏瀛鹏, 胡雨来, 傅颖, 杜正银, 王进贤   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2015-07-17 修回日期:2015-10-13 出版日期:2016-01-25 发布日期:2015-12-10
  • 通讯作者: 王克虎, 胡雨来 E-mail:wangkh@nwnu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21262031)资助项目.

Study on the Grinding-Induced Solvent-Free Preparation of 3-Styryl-1,5-diketones

Wang Kehu, Yin Xuejiao, Tao Rui, Huang Danfeng, Su Yingpeng, Hu Yulai, Fu Ying, Du Zhengyin, Wang Jinxian   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2015-07-17 Revised:2015-10-13 Online:2016-01-25 Published:2015-12-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21262031).

在无溶剂条件下, α,β-不饱和醛与芳香酮在室温下研磨得到2,4-共轭二烯酮, 随后, 2,4-共轭二烯酮与过量芳香酮在NaOH存在下进一步发生Michael加成反应, 快速而高效地合成了3-芳乙烯基-1,5-二酮类化合物. 该法与传统的溶液法相比具有不使用溶剂和催化剂, 反应条件温和, 反应时间短, 操作简便等优点.

关键词: 无溶剂, 研磨, Aldol-Michael加成, 1,5-二酮

A convenient procedure for the synthesis of 3-styryl-1,5-dicarbonyl compounds has been developed under solvent-free grinding conditions. α,β-Unsaturated aldehydes react with aromatic ketones to give the corresponding dienone products, then followed by a Michael addition producing 3-styryl-1,5-dicarbonyl compounds in the presence of NaOH at room temperature. The advantages of this procedure are solvent-free, catalyst-free, mild reaction conditions, simple procedure, and short reaction time.

Key words: solvent-free, grinding, aldol-Michael addition, 1,5-diketones