有机化学 ›› 2016, Vol. 36 ›› Issue (6): 1208-1217.DOI: 10.6023/cjoc201512029 上一篇    下一篇

综述与进展

路易斯碱有机小分子催化亚胺的不对称还原研究进展

葛新a,b, 陈新志b, 钱超b   

  1. a 江南大学化学与材料工程学院无锡 214122;
    b 浙江大学生物质化工教育部重点实验室杭州 310027
  • 收稿日期:2015-12-21 修回日期:2016-01-26 出版日期:2016-06-25 发布日期:2016-02-02
  • 通讯作者: 钱超 E-mail:qianchao@zju.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21376213,21476194)、浙江省科技厅公益性技术应用研究计划项目(Nos.2014C31123,2015C31038)、江南大学自主科研计划(No.JUSRP115A05)资助项目.

Progress on the Lewis-Basic Organocatalytic Asymmetric Reduction of Imines

Ge Xina,b, Chen Xinzhib, Qian Chaob   

  1. aSchool of Chemical and Material Engineering, Jiangnan University, Wuxi 214122;
    b Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027
  • Received:2015-12-21 Revised:2016-01-26 Online:2016-06-25 Published:2016-02-02
  • Supported by:

    Project supported by the Natural Science Foundation of China (Nos. 21376213, 21476194), Zhejiang Provincial Public Technology Research of China (Nos. 2014C31123, 2015C31038) and the Fundamental Research Funds for the Central Universities (No. JUSRP115A05).

近年来, 路易斯碱有机小分子催化的亚胺不对称还原反应, 因氢源廉价和后处理简单等优点而受到关注. 分别介绍了甲酰胺类、吡啶酰胺类、亚磺酰胺类、非酰胺类以及负载型路易斯碱有机小分子催化剂在亚胺不对称还原中的应用, 并且对催化剂的结构特点、催化活性及催化机理等方面展开了论述.

关键词: 亚胺, 路易斯碱, 有机催化剂, 不对称还原

Recently, the asymmetric reduction of imines catalyzed by Lewis-basic organocatalyst has been received much attention as the cheap hydrogen source and the simple post treatment. Based on the different functional groups of organocatalysts, this paper introduced formamide, pyridine amide, sulfonamide, supported and other Lewis basic organocatalysts. The structural characteristics, catalytic activity and mechanism of the Lewis-basic organocatalysts were summarized.

Key words: imine, Lewis-base, organocatalyst, asymmetric reduction