有机化学 ›› 2017, Vol. 37 ›› Issue (6): 1382-1391.DOI: 10.6023/cjoc201612031 上一篇    下一篇

综述与进展

过渡金属催化的偶联反应在合成C-糖苷中的应用

廖进喜, 刘慧, 孙建松   

  1. 江西师范大学国家单糖化学合成工程技术研究中心 南昌 330022
  • 收稿日期:2016-12-08 修回日期:2017-02-13 出版日期:2017-06-25 发布日期:2017-02-27
  • 通讯作者: 孙建松 E-mail:jssun@jxnu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21202166)和江西省教育厅科学技术研究(No.GJJ150328)资助项目.

Applications of Transition Metal Catalyzed Coupling Reactions in the Synthesis of C-Glycosides

Liao Jinxi, Liu Hui, Sun Jiansong   

  1. National Engineering Research Center for Carbohydrate Synthesis, Jianxi Normal University, Nanchang, 330022
  • Received:2016-12-08 Revised:2017-02-13 Online:2017-06-25 Published:2017-02-27
  • Contact: 10.6023/cjoc201612031 E-mail:jssun@jxnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21202166) and the Science and Technology Project Founded by the Education Department of Jiangxi Province (No. GJJ150328).

C-糖苷是指糖苷键的环外氧原子被碳所取代的一类化合物的总称,其结构单元广泛存在于天然产物和药物分子中.与相应的O-糖苷和N-糖苷相比,C-糖苷具有更好的酶稳定性以及耐水解性能.由于其独特的化学结构和广泛的应用价值,其合成方法的研究已经成为当今糖化学领域的一个研究热点.主要对过渡金属催化的偶联反应构建C-糖苷的方法进行综述,试图归纳总结出不同合成方法的特点以及不足,为过渡金属催化C-糖苷的进一步合成研究提供帮助.

关键词: C-糖苷, 合成, 过渡金属催化, 偶联反应

C-Glycosides in which the interglycosidic oxygen atom have been replaced by carbon atom are widely found in natural products and drug molecules. They have better enzymatic and hydrolytic stablility compared to their corresponding O-glycosides and N-glycosides. The syntheses of them have received considerable attention because of their unique chemical structure and extensive application value. Rencent advances in the synthesis of C-glycosides through coupling reactions catalyzed by transition metal are summarized in this review. A summary of the advantages and disadavatages of different synthetic methods will be beneficial to the develepment of new synthetic method for C-glycosides.

Key words: C-glycosides, synthesis, transition metal catalyzed, coupling reactions