有机化学 ›› 2017, Vol. 37 ›› Issue (5): 1088-1098.DOI: 10.6023/cjoc201702040 上一篇    下一篇

综述与进展

烷基Heck反应研究进展

董旭a,b, 侯永正a, 孟凡威a, 刘洪波a, 刘会a,b   

  1. a 湖南大学材料科学与工程学院 长沙 410082;
    b 山东理工大学化学与工程学院 淄博 255049
  • 收稿日期:2017-02-26 修回日期:2017-03-23 出版日期:2017-05-25 发布日期:2017-04-13
  • 通讯作者: 刘会 E-mail:huiliu1030@sdut.edu.cn
  • 基金资助:

    中国博士后科学基金(No.2016M590736)和山东省博士后创新项目专项资金(No.201501002)资助项目.

Recent Advances on Alkyl-Heck Reaction

Dong Xua,b, Hou Yongzhenga, Meng Fanweia, Liu Hongboa, Liu Huia,b   

  1. a College of Materials Science and Engineering, Hunan University, Changsha 410082;
    b School of Chemical Engineering, Shandong University of Technology, Zibo 255049
  • Received:2017-02-26 Revised:2017-03-23 Online:2017-05-25 Published:2017-04-13
  • Contact: 10.6023/cjoc201702040 E-mail:huiliu1030@sdut.edu.cn
  • Supported by:

    Project supported by the China Postdoctoral Science Foundation (No. 2016M590736) and the Special Funding for Postdoctoral Innovation Project of Shandong Province (No. 201501002).

在最近几年,钯催化的烷基Heck反应在构建C(sp3)-C(sp2)键领域被越来越多的化学工作者所关注.该综述总结归纳了涉及钯催化的烷基Heck型反应,主要分为分子内反应和分子间反应两大部分介绍,并详细讨论了多数转化的反应机理.希望通过该综述让更多的化学工作者了解钯自由基参与的Heck反应,并促进该领域的发展.

关键词: 钯催化, 自由基, Heck反应, 烷基卤化物

Recently, palladium-catalyzed alkyl-Heck reaction causes more attentions due to the wide application in the construction of C(sp3)-C(sp2). This review gives an up-to-date overview of alkyl-Heck reaction involving palladium radical intermediates, which are sorted in two categories of intramolecular reactions and intermolecular reactions. For most of these transformations, the plausible mechanisms are demonstrated in details. Clarification of these issues is the key point for understanding the palladium radical involved alkyl-Heck reactions and developing new high performance methodologies.

Key words: Pd-catalyzed, radical, Heck reaction, alkyl halide