有机化学 ›› 2019, Vol. 39 ›› Issue (5): 1429-1435.DOI: 10.6023/cjoc201810011 上一篇    下一篇

研究论文

强酸性阳离子交换树脂催化水相法合成双吲哚甲烷类衍生物

张瑞泽a, 王国栋a, 李洪爽a, 段桂运a, 王凯a, 夏成才a,b   

  1. a 山东第一医科大学(山东省医学科学院)药学院 泰安 271016;
    b 山东第一医科大学(山东省医学科学院)药理研究所 泰安 271016
  • 收稿日期:2018-10-11 修回日期:2018-12-18 出版日期:2019-05-25 发布日期:2019-01-18
  • 通讯作者: 夏成才 E-mail:xiachc@163.com
  • 基金资助:

    山东省医药卫生科技发展计划(No.2015WS0102)资助项目.

Strong-Acid Cation Exchange Resin Catalyzed Synthesis of Bis(indolyl)methanes in Water

Zhang Ruizea, Wang Guodonga, Li Hongshuanga, Duan Guiyuna, Wang Kaia, Xia Chengcaia,b   

  1. a Pharmacy College, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016;
    b Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016
  • Received:2018-10-11 Revised:2018-12-18 Online:2019-05-25 Published:2019-01-18
  • Contact: 10.6023/cjoc201810011 E-mail:xiachc@163.com
  • Supported by:

    Project supported by the Medical and Health Technology Development Program in Shandong Province (No. 2015WS0102).

开发了一种通过强酸性离子交换树脂催化将苯甲醛和吲哚转化成双吲哚甲烷类衍生物的有效合成方法,它是以水作为溶剂,实现了催化剂可循环使用6次,以较高收率得到了多种双吲哚甲烷化合物.

关键词: 强酸性阳离子交换树脂, 吲哚, 双吲哚甲烷, 缩合

An efficient protocol for conversion of aldehyde and indole into bis(indolyl)methanes derivatives catalyzed by strong-acid cation exchange resin has been developed. The H2O was used as solution and recycle catalyst can be used six times. Various bis(indolyl)methanes derivatives were obtained in excellent yields.

Key words: strong-acid cation exchange resin, indole, bis(indolyl)methanes, condensation