有机化学 ›› 2019, Vol. 39 ›› Issue (7): 2070-2074.DOI: 10.6023/cjoc201812039 上一篇    下一篇

研究简报

含肟醚的松油烯-4-醇衍生物的合成及杀虫活性

雷鹏, 丁新吉, 吴远勇, 马志卿   

  1. 西北农林科技大学植物保护学院 杨凌 712100
  • 收稿日期:2018-12-21 修回日期:2019-01-21 出版日期:2019-07-25 发布日期:2019-03-29
  • 通讯作者: 马志卿 E-mail:mazhiqing2000@126.com
  • 基金资助:

    国家自然科学基金(No.31572029)、西北农林科技大学科研启动费(No.00200-Z109021809)资助项目.

Synthesis and Insecticidal Activity of Terpinen-4-ol Derivatives Containing Oxime Ether

Lei Peng, Ding Xinji, Wu Yuanyong, Ma Zhiqing   

  1. College of Plant Protection, Northwest A & F University, Yangling 712100
  • Received:2018-12-21 Revised:2019-01-21 Online:2019-07-25 Published:2019-03-29
  • Contact: 10.6023/cjoc201812039 E-mail:mazhiqing2000@126.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 31572029) and the Starting Research Fund from the Northwest A&F University (No. 00200-Z109021809).

为发现具有较高杀虫活性的先导化合物,结合本课题组前期研究结果,设计合成了系列含肟醚的松油烯-4-醇衍生物,并测试了杀虫活性.结果表明,目标化合物对粘虫具有较好的触杀作用,其中化合物2-甲基-5-异丙烯基-2-环己烯-1-酮肟-O-炔丙基醚(3a)的LD50值为0.0054 mg/头,毒力是松油烯-4-醇的19.1倍,可以作为农药先导化合物进一步优化研究.

关键词: 肟醚, 松油烯-4-醇, 天然产物, 生物活性, 粘虫

In order to discover high activity lead compound, based on our previous studies, a series of terpinen-4-ol deri- vatives containing oxime ether were designed and synthesized. The bioassay results showed that the target compounds displayed good insecticidal activity against Mythimna separata (Walker). Especially, compound 3a exhibited satisfied activity with the LD50 value of 0.0054 mg/insect, which is 19.1 times than terpinen-4-ol. As a high activity compound with simple structure, 2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one O-prop-2-yn-1-yl oxime (3a) could be a lead compound for further study.

Key words: oxime ether, terpinen-4-ol, natural product, biological activity, Mythimna separata