The recent progresses in the $\alpha$-C(sp3)—H bond functionalization of glycine derivatives are reviewed by Zhu, Xiao, Xie and Le on page 2345. The reactions of glycine derivatives with various coupling partners, including C(sp3), C(sp2), C(sp), N, P, S and others, to form carbon-carbon or carbon-heteroatom bond through $\alpha$-C(sp3)—H bond functionalization are summarized, with their scope of substrates and reaction mechanism.