Chin. J. Org. Chem. ›› 2012, Vol. ›› Issue (03): 593-596.DOI: 10.6023/cjoc1101201 Previous Articles     Next Articles



龚景旭, 盛丽, 姚励功, 李佳, 周宇波, 郭跃伟   

  1. 中国科学院上海药物研究所 新药研究国家重点实验室 上海 201203
  • 收稿日期:2011-01-20 修回日期:2011-11-08 发布日期:2012-03-24
  • 通讯作者: 于萍
  • 基金资助:

    国家新药创制重大专项(No. 2009ZX09301-00, 2009ZX09103-060)、国家自然科学基金(Nos. 81072572, 21072204, 21021063)、国家海洋“863”计划(No.2011AA09070102)、上海市科委基础研究(Nos. 09ZR1438000, 10540702900)和中国科学院重点(Nos. KSCX2-EW-R-15, KSCX2-YW-R-18)资助项目.

Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides

Gong Jingxu, Sheng Li, Yao Ligong, Li Jia, Zhou Yubo, Guo Yuewei   

  1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203
  • Received:2011-01-20 Revised:2011-11-08 Published:2012-03-24
  • Supported by:

    Project supported by the National S & T Major Project (Nos. 2009ZX09301-001, 2009ZX09103-060), the Natural Science Foundation of China (Nos. 81072572, 21072204, 21021063), the National Marine “863” Project (No. 2011AA09070102), the Basic Research Project of Shanghai Science and Technology Commission (Nos. 09ZR1438000, 10540702900), and the Key Program of the Chinese Academy of Sciences (Nos. KSCX2-EW-R-15, KSCX2-YW-R-18).

A series of alkyl heterocyclyl disulfides were prepared by reaction of the heterocyclyl thiol with Bunte salts. All the synthesized compounds showed interesting inhibit activities toward human colon carcinoma cells (HCT-116) in vitro. The IC50 values of the tested compounds ranged from 4.8 μg·mL-1 to 17.7 μg·mL-1.

Key words: disulfides, synthesis, anti-tumor activity