Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (05): 852-859.DOI: 10.6023/cjoc1107221 Previous Articles     Next Articles



涂永元a,b, 徐先祥a,b, 邱飞a,b   

  1. a 华侨大学分子药物学研究所 泉州 362021;
    b 分子药物教育部工程研究中心 泉州 362021
  • 收稿日期:2011-07-22 修回日期:2011-11-02 出版日期:2012-05-25 发布日期:2011-12-12
  • 通讯作者: 邱飞
  • 基金资助:

    国家自然科学基金(No. 30900351)、福建省自然科学基金(No. 2009J05029)、福建省生物医药工程研究生教育创新基地(No. 06070205)和华侨大学科研基金(No. 08BS412)资助项目.

Research Progress in the Prodrugs of Curcumin

Tu Yongyuana,b, Xu Xianxianga,b, Qiu Feia,b   

  1. a Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021;
    b Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou 362021
  • Received:2011-07-22 Revised:2011-11-02 Online:2012-05-25 Published:2011-12-12
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 30900351), the Natural Science Foundation of Fujian Province of China (No. 2009J05029), the Fujian Biomedicial Engineering Graduate Student’s Educational Innovation Base (No. 06070205) and the Scientific Research Foundation of Huaqiao University (No. 08BS412).

In recent years, curcumin, a natural product, has been drawing attention from researchers for it has many kinds of significant bioactivities, such as antitumor activity. However, its clinical utility is limited due to a number of undesirable difficulties, such as its low aqueous solubility, instability and low bioavailability. Through conjugated the phenolic hydroxyl group of curcumin with low or high molecular weight carriers, various prodrugs of curcumin have been studied and developed to overcome its disadvantages. The development of prodrugs of curcumin was an effective method to improve the druggability of curcumin. In this paper, the research progresses in the prodrugs of curcumin in recent years are reviewed.

Key words: curcumin, prodrugs, medicinal chemistry, antitumor drug