Chin. J. Org. Chem. ›› 2012, Vol. ›› Issue (03): 532-537.DOI: 10.6023/cjoc1108102 Previous Articles     Next Articles



刘长娥a, 于琪瑶b, 唐健红a,c, 李加荣a   

  1. a 北京理工大学化工与环境学院 北京 100081;
    b 北京理工大学化学学院 北京100081;
    c 华侨大学化工学院 厦门 362021
  • 收稿日期:2011-08-10 修回日期:2011-11-21 发布日期:2012-03-24
  • 通讯作者: 李加荣

One-Pot Synthesis of 4(3H)-Quinazolinone under Base Condition

Liu Changea, Yu Qiyaob, Tang Jianhonga,c, Li Jiarong a   

  1. a School of Chemical Engineering and Environment, Beijing Institude of Technology, Beijjing 100081;
    b School of Chemistry, Beijing Institude of Technology, Beijjing 100081;
    c College of Chemical Engineering, Huaqiao University, Xiamen 362021
  • Received:2011-08-10 Revised:2011-11-21 Published:2012-03-24

A series of 4(3H)-quinazolinones 3 were obtained from the one-pot synthesis of available substituted aromatic o-aminonitriles 1 with aldehydes 2 in the present of base. This tandem transformation was included in addition, intramolecular Pinner reaction, Dimroth rearrangement and oxidative dehydrogenation. The structures of products were characterized by 1H NMR, 13C NMR, IR spectra and elemental analysis.

Key words: one-pot synthesis, aromatic o-aminonitrile, aldehyde, base catalysis, 4(3H)-quinazolinone