Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (10): 1988-1992.DOI: 10.6023/cjoc201204015 Previous Articles     Next Articles



万阳, 文鹏, 张攀, 陆群   

  1. 西南交通大学生命科学与工程学院 成都 610031
  • 收稿日期:2012-04-12 修回日期:2012-06-06 出版日期:2012-10-25 发布日期:2012-06-19
  • 通讯作者: 陆群
  • 基金资助:

    四川省科技支撑基金(No. 2010SZ124)资助项目.

Novel Synthesis of Paricalcitol by Chem-biotransformation

Wan Yang, Wen Peng, Zhang Pan, Lu Qun   

  1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
  • Received:2012-04-12 Revised:2012-06-06 Online:2012-10-25 Published:2012-06-19
  • Supported by:

    Project supported by the Science and Technology Support Fundation of Sichuan Province (No. 2010SZ124).

Paricalcitol (9) was obtained from Vitamin D2 via a route of the combination of seven-step organic reaction and biotransformation. The overall yield was 3.24%, which was higher than those of the reported methods. The structures of all intermediates and product were confirmed by 1H NMR, 13C NMR and MS techniques.

Key words: vitamin D2, hydroxylation, paricalcitol