Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (11): 2171-2176.DOI: 10.6023/cjoc201206003 Previous Articles     Next Articles



高文涛, 陶希月, 林贵海, 李阳   

  1. 渤海大学超精细化学品研究所 锦州 121000
  • 收稿日期:2012-06-05 修回日期:2012-07-04 发布日期:2012-07-11
  • 通讯作者: 高文涛
  • 基金资助:

    辽宁省自然科学基金(No. 2012S001)资助项目.

A Facile Synthesis of Novel Pyridine-2,6-diylbis(1-benzofuran-2- ylmethanone) Derivatives under Ultrasonic Conditions

Gao Wentao, Tao Xiyue, Lin Guihai, Li Yang   

  1. Institute of Superfine Chemicals, Bohai University, Jinzhou 121000
  • Received:2012-06-05 Revised:2012-07-04 Published:2012-07-11
  • Supported by:

    Project supported by the Natural Science Foundation of Liaoning Province (No. 2012S001).

A facile synthesis of unreported pyridine-2,6-diylbis(benzofuran-2-ylmethanone) derivatives was described. The synthesis mainly relied on the ultrasound-assisted Rap-Stoermer reaction of 1,1'-(pyridine-2,6-diyl)bis(2-bromoethanone) with a variety of salicylaldehydes in MeCN at the presence of PEG-400. This procedure offered easy access to construct new prototypes containing methanone linker between the benzo(naphtho)furan ring and pyridine moiety at 2,6-position in a short reaction time and mild conditions with good yields. Compound structures were identified by means of 1H(13C) NMR, IR and elemental analysis.

Key words: 1,1'-(pyridine-2,6-diyl)bis(2-bromoethanone), benzo(naphtho)furan, carbonyl group, ultrasound-assisted, Rap- Stoermer reaction